From Mechanism to Management: Navigating Male Pattern Hair Loss and New Topical Therapies

madman

Super Moderator

In this Dermatology Times Expert Perspectives video series, Joshua Zeichner, MD, associate professor of dermatology at Mount Sinai Hospital in New York City, breaks down the key aspects of managing androgenetic alopecia (male pattern hair loss).Zeichner discusses:


• Biological Mechanisms: How genetic susceptibility and sensitivity to dihydrotestosterone (DHT) drive progressive hair follicle miniaturization along the crown and frontal hairline.

• Psychosocial Impact: Why hair loss is far more than a cosmetic concern, deeply affecting self-esteem, self-identity, and patient confidence.

• Navigating Misinformation: The importance of choosing clinically tested, board-certified treatments over unsubstantiated social media claims.

• Emerging Therapies: A look into Phase 3 data for clascoterone 5% solution—an investigational topical androgen receptor inhibitor designed to target local DHT signaling in the follicle without systemic hormonal side effects.






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