free T 25/ total T 500, advice on couple things pls

lukas_az

Member
3-4months in on TRT now.
overall I feel pretty good/energetic with some swings, but always looking to fine-tune things, what do you think of my regimen?
on TRT, 40mg 3x week. last dose Friday. blood taken Monday morning:
total T: 507 ng/dl
free T; 24.2 pg/ml
DHEA sulfate: 537 ug/dl (says high, taking 10mg DHEA in the AM)
Estradiol sensitive: 37.3 pg/ml
SHBG: 11.1 nmol/l (says low)
other interesting findings:
my eGFR is 111 which is good. I was 100 pre-trt, and 90 2 years ago.
bun/creatinine ratio = 29 (high)
RBC - 6.22 (high)
hemoglobin - 17.9 (high)
hematocrit - 56.7 (high) - will going to daily regimen with TRT improve it? donate blood? i have no side effects tht I feel
alkaline phospatase: 47 (low)

everything else is very good, no health issues, on high fat/meat diet (carnivore/keto)
my cholesterol is pretty high, but I do not care/think this is a problem TBH.
 
Last edited:
hematocrit - 56.7 (high) - will going to daily regimen with TRT improve it?
Maybe, it's does the trick for some men. I would greatly reduce your dosage if considering a daily regime, something like 12-16mg daily.

You don't need high normal Total T to have high normal Free T because your SHBG is very low, a 400 Total T would still get you good Free T levels.
 
thank you. seeing what the DOC says. but it would make sense, my free T is pretty high and that would explain why I am seeing all the benefits of TRT.
i am reading that low SHBG could be related to insulin/metabolic issues which I always had. don't have D2 but I probably would have it if not low carb diet by now
 

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This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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