Erectile Dysfunction Risk Linked To How Many Medications You Take

Nelson Vergel

Founder, ExcelMale.com
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A study found that as the number of medications men took increased, so did the prevalence of ED, the authors reported - across all age groups:


Medications taken: 0 to 2. Number of participants 16,126.
Proportion with moderate ED - 15.9%

Medications taken: 3 to 5. Number of participants 10,046.
Proportion with moderate ED - 19.7%

Medications taken: 6 to 9. Number of participants 6,870.
Proportion with moderate ED - 25.5%

Medications taken: 10 or more. Number of participants 4,670.
Proportion with moderate ED - 30.9%


The following drugs are most commonly linked to ED:

Antihypertensive drugs, such as thiazides, beta blockers, and clonidine.

Psychogenic drugs, such as SSRIs (selective serotonin reuptake inhibitors), tricyclic antidepressants, monoamine oxidase inhibitors, and lithium

57% of the men in the survey were on more than three different drugs. The older the participants, the more likely they were to be on over three medications.


Percentage of men on more than three medications according to age:

50 to 59 years - 53%
60 to 70 years - 66%


Erectile Dysfunction Risk Linked To How Many Medications Are Taken
 
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Drugs that can cause erectile dysfunction and Potential Causes of Erectile Dysfunction
 

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ED Study Summary Table of Several Medications

The attached table presents a summary of many studies done to assess the effect (positive or negative) of several medications and medication classes on erectile function. The 11th column lists the compound or class.

In general, most blood pressure medications, antidepressants, antiepileptic agents, alcohol, nicotine and others have been investigated and found to cause ED.

Source: Drugs Compromising Male Sexual Health, by Walter K.H. Krause.

Drugs that cause ED.webp
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

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The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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