Erectile Dysfunction and Phosphodiesterase Type 5 Inhibitor Use

Nelson Vergel

Founder, ExcelMale.com
"Although the majority of PDE5i users in ELSA reported the effect of these medications on their sex lives as positive, when compared with men without ED they consistently reported higher levels of concern and dissatisfaction with various aspects of their sexual activity, function and relationships. Few comparable data on community-dwelling men are available, but a study among Australian men recruited over the internet via men's health web sites found that treatment of ED with PDE5i medications did not alleviate deficits in assessments of self-esteem, masculinity, quality of life, sexual satisfaction and relationship satisfaction.[SUP][25][/SUP] There is an increasing recognition that the most common type of ED seen clinically is of a 'mixed' aetiology, that is, representing a combination of organic and psychogenic causes.[SUP][26][/SUP]Our population data add to the evidence base that PDE5i use does not simply translate to a uniformly better sex life, supporting the view that ED arises from a mixture of physiological, psychological and social causes. However, primary care physicians typically neglect this complexity when treating many cases of ED.[SUP][26][/SUP] Time constraints on general practitioners consultation time and an unwillingness among primary care health professionals to discuss sexuality and sexual health with older individuals[SUP][27,28][/SUP]only compounds this situation, resulting in suboptimal treatment and follow-up for many men with ED. "

http://www.medscape.com/viewarticle/848821_4
 

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Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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