Enclomiphene vs TRT: Where Does It Really Fit in Today’s HRT Landscape?

madman · 2026-02-17T17:00:15-0600

Mohit Khera's personal experience with enclomiphene

HPTA

Conclusion

madman · 2026-02-17T17:01:31-0600

Testosterone Utilization in Reproductive Years

madman · 2026-02-17T17:04:50-0600

AUA Urologist and TRT Practices

madman · 2026-02-17T17:06:01-0600

Studies in Male Contraception: Testosterone

madman · 2026-02-17T17:14:21-0600

Mohit Khera

* what we found is that you don't see a significant suppression in LH and FSH and more importantly you don't see a significant suppression in spermatogenesis so yet your giving exogenous testosterone but not suppressing spermatogenesis

* In all fairness 20% of the patients in this trial so far have become azoospermic but we are starting to see signs of a medication, one of the exogenous testosterones that may not significantly suppress spermatogenesis as bad as other exogenous testosterone products

Oral TU Efficacy at Final PK Visit

2025 Abstract

madman · 2026-02-17T17:16:13-0600

Testosterone Alternatives: Medical Therapies

madman · 2026-02-17T17:27:21-0600

Preventing Infertility

hCG and Intratesticular T

TTh and HCG Preserves Fertility

Mohit Khera

* but don't be fooled if you read are manuscript there were patents that became azoospermic, this is an average right, so don't tell patients if you take hCG with your testosterone everything is going to be fine but the MAJORITY of men did see preservation or spermatogenesis by taking the hCG

Follow-up study presented last year at AUA 2025

* the take-home is look at the azoospermic rate

madman · 2026-02-17T17:36:56-0600

* men NEED ESTROGEN for LIBIDO

hCG vs Clomid

Clomid is the TRUE KICKSTART

madman · 2026-02-17T17:40:00-0600

Clomid studies

madman · 2026-02-17T17:45:26-0600

Clomiphene vs Enclomiphene

3 studies

madman · 2026-02-17T17:48:09-0600

Study

madman · 2026-02-17T17:51:59-0600

Mohit Khera study 2025

Mohit Kheras personal experience with enclomiphene

madman · 2026-02-17T17:54:17-0600

Conclusion

madman · 2026-02-17T17:57:33-0600

Post in thread 'Clomiphene citrate: A potential alternative for TRT in men with low testosterone'

Mar 31, 2023

Improvements in semen parameters in men treated with clomiphene citrate—A retrospective analysis - Excel Male Health Forum

www.excelmale.com

Enclomiphene citrate: A treatment that maintains fertility in men with secondary hypogonadism - Excel Male Health Forum

ABSTRACT Introduction: Hypogonadism is an important issue among the male population. Treatments such as exogenous testosterone have become very popular. One of the adverse effects of testosterone is its suppression of fertility. This has led to the use of alternative therapies such as selective...

www.excelmale.com

Treating Low Testosterone with Clomid, hCG and Aromatase Inhibitors: A Review of the Data - Excel Male Health Forum

Abstract Testosterone deficiency is defined as a total testosterone level <300 ng/dL confirmed on two early morning lab draws. Testosterone therapy has historically been offered to men with symptomatic testosterone deficiency in the form of injections, gels, or pellets. However, these...

www.excelmale.com

A paradoxical decline in semen parameters in men treated with clomiphene citrate (Clomid) - ExcelMale Forum. TRT, Hormones, Peptides, Men’s Health

A paradoxical decline in semen parameters in men treated with clomiphene citrate Tejas Gundewar | Manish Kuchakulla | Ranjith Ramasamy Abstract Clomiphene, a selective estrogen receptor modulator, has been utilized in managing male sub-fertility since 1967. Numerous controlled and...

www.excelmale.com

...

Thread 'Enclomiphene citrate: A treatment that maintains fertility in men with secondary hypogonadism'

May 8, 2019

ABSTRACT

Introduction: Hypogonadism is an important issue among the male population. Treatments such as exogenous testosterone have become very popular. One of the adverse effects of testosterone is its suppression of fertility. This has led to the use of alternative therapies such as selective estrogen receptor modulators (SERMs) that aim to correct hypogonadism without reducing fertility.

Areas covered: The SERM, clomiphene citrate, which is approved by the FDA for the treatment of ovarian dysfunction, has been shown to have beneficial effects on male...