Effects of High vs Low Glycemic Index of Dietary Carb on Cardiovascular Disease Risk Factors

[croaker24]

Full title: Effects of High vs Low Glycemic Index of Dietary Carbohydrate on Cardiovascular Disease Risk Factors and Insulin Sensitivity @ http://jama.jamanetwork.com/article.aspx?articleid=2040224

Conclusions and Relevance In this 5-week controlled feeding study, diets with low glycemic index of dietary carbohydrate, compared with high glycemic index of dietary carbohydrate, did not result in improvements in insulin sensitivity, lipid levels, or systolic blood pressure. In the context of an overall DASH-type diet, using glycemic index to select specific foods may not improve cardiovascular risk factors or insulin resistance.

Here's is Dr David Katz's thoughts on this trial:

http://health.usnews.com/health-new...rial-reductionism-revelations-and-resolutions

A second implication is that carbohydrate is not the be-all, end-all when it comes to insulin sensitivity. With all the ranting these days about the insidious evils of carbohydrate, this may seem surprising; but it, too, is a long-established fact. Consumption of protein triggers insulin release, generally more so than does carbohydrate. The lower-carbohydrate assignments in OmniCarb were higher in protein, and effects of the latter on insulin requirements may have more than offset the former.

 

[Vince]

I agree, too much protein can triggers insulin release.
Hyperglycemia/type 2 diabetes–The formula to make a person diabetic is simple: eat foods that raise blood sugar and insulin, resistance to insulin develops, visceral fat grows that adds to inflammation that further blocks insulin, fatty liver develops (due to liver de novo lipogenesis) that also further blocks insulin, and blood sugars rise to the diabetic range. The process is therefore started by foods that raise blood sugar the highest. What foods have the highest glycemic index (and glycemic loads) of all foods? Grains–even more so than white table sugar. Follow a diet dominated or rich in grains, white or whole, and blood sugars go up many times per day (since there is virtually no difference from a blood sugar perspective): a perfect setup for type 2 diabetes. Get rid of all wheat and grains and the entire cycle unwinds.
I copied this from an e-mail I received yesterday.

 

[Jay]

Croaker,

" Consumption of protein triggers insulin release, generally more so than does carbohydrate"

It is funny the advancements that we make in technology, science, etc, but we can't crack this nut!

 

[hdrider]

Perhaps an alternate explanation as to why low carb diets work:

http://wholehealthsource.blogspot.com/2013/04/glucagon-dietary-protein-and-low.html

 

[croaker24]

This gets to be ridiculous - the human body / nutrition / our genome and long evolution through all kinds of climate change and resulting changes in available food supplies, is far too complicated for this kind of reductionism. Did you know for example - we used to be able to manufacture our own Vitamin C, but lost that ability when we encountered plentiful resources for it? I guess sort of how we lose our ability to manufacture T when on TRT? A poor analogy I admit, but still.

I don't think most people understand just how much our biome evolved - and changed dramatically over the past 100 years due to things such as living in cities, improved sanitation, and antibiotics which has resulted in dysfunctional immune systems as a result of no longer having all these parasites, bacteria, and worms that we carried for a long time. H pylori anyone? The guy who causes ulcers? Yet - they've found you eradicate it you can cause all kinds of other issues, such as GERD and esophageal cancer.

It's not wheat, it's not fat, or carbs, or dairy, or GMOs that has caused the dramatic increase in autoimmune diseases and allergies - it's the big change in human ecosystems - our bacteria plays a far more greater role in our health than we realize.

This is all a moving target anyway - 25 years from now, people will look back at these diet fads and laugh at our naivete - to fix our problems we'll be getting targeted probiotics based on our genome; the big frontier is to repair the biome.

To me - the best article today was this - talking about should we believe in all these health studies.

http://www.nytimes.com/2015/08/18/u...lth-study.html?ref=health&_r=0&abt=0002&abg=0

One thing this article left out was those folks like Dr Greger of nutritionfacts.com who perform these systemic type of research - which to me basically is nothing more than cherry-picking - hunting down articles that supports your cause and ignoring those that contradict it.

 

[Vince]

Another possibility, suggested by Linus Pauling, is that Lp(a) is a primate adaptation to L-gulonolactone oxidase (GULO) deficiency, found only in certain lines of mammals. GULO is required for converting glucose to ascorbic acid (vitamin C), which is needed to repair arteries; following the loss of GULO, those primates that adopted diets less abundant in vitamin C may have used Lp(a) as an ascorbic-acid surrogate to repair arterial walls.


However, individuals without Lp(a) or with very low Lp(a) levels seem to be healthy. Thus, plasma Lp(a) is not vital, at least under normal environmental conditions. Since apo(a)/Lp(a) derived rather recently in mammalian evolution - only old world monkeys and humans have been shown to harbour Lp(a) - its function might not be vital but just evolutionarily advantageous under certain environmental conditions, e.g. in case of exposure to certain infectious diseases.