Effectiveness of micronized purified flavonoid fraction on venous symptoms and signs in patients at all stages of chronic venous disease

madman · 2025-12-27T17:23:28-0600

Effectiveness of micronized purified flavonoid fraction on venous symptoms and signs in patients at all stages of chronic venous disease: a systematic review and meta-analysis (2025)
Andrew NICOLAIDES, Kirill LOBASTOV, Armando MANSILHA, Alejandro J. GONZALEZ-OCHOA, Vanessa BLANC-GUILLEMAUD, Marie-Blanche ONSELAER, Soumeya SERIFOU, Hurrem P. YALTIRIK, Narayanan SRIRAM, Lianrui GUO, Stavros KAKKOS

Part I: symptoms

Conclusions

This large systematic review and meta-analysis of RCTs and non-RCTs focusing on CVD symptoms demonstrates that daily treatment with MPFF 1000 mg leads to significant symptoms improvement in patients with CVD at all stages of the disease. In addition, high levels of satisfaction (at least 90%) with MPFF treatment were reported by patients. These findings provide robust evidence of significant symptomatic benefit with MPFF in a wide range of patient profiles across all classes of CVD.

Part II: signs

Conclusions

In this meta-analysis, treatment with MPFF in association with standard of care therapy was found to provide significant improvements in leg edema, skin changes and the healing of venous ulcers. These findings ensure a broad overview of the effectiveness of MPFF treatment on clinical signs of CVD across a range of study designs, including RCTs and real-world studies in various patient profiles.

madman · 2025-12-27T17:27:38-0600

Thread 'Heavy, Achy, Swollen Legs? Varicose Veins & Venous Insufficiency Explained — Symptoms, Causes, and the Best Treatments for Lasting Relief'

Sep 22, 2025

Do your legs feel heavy, achy, or swollen by the end of the day? Have you noticed bulging varicose veins or skin changes near your ankles? These could be early warning signs of chronic venous insufficiency (CVI) — a condition where the valves in your veins stop working properly and blood pools in your legs.

In this episode, Dr. John Chuback, board-certified cardiovascular surgeon, explains what venous insufficiency really is, why it happens, and the symptoms you should never ignore. We’ll also walk through the best treatment options —...