Effect of TRT vs hCG/FSH on upstream hormone pathways.

[Fernando Almaguer]

Thread 'Dose-Dependent Rise in 17-Hydroxyprogesterone: Insights from hCG Therapy in Testosterone-Treated Men'

Apr 11, 2025

* Human chorionic gonadotropin (hCG) therapy can be co-administered with TTh to maintain spermatogenesis, testicular size, or libido, but no study has assessed associated 17-OHP levels in these men on concurrent TTh and hCG therapy. levels in men on TTh.


* In our practice, hCG 1500 IU subcutaneous injection is prescribed once weekly to maintain spermatogenesis while on TTh, 1500 IU twice weekly to restore testicular size or improve libido while on TTh, or 3000 IU three times weekly plus FSH and TTh when attempting to reboot spermatogenesis after TTh therapy allowing...

• madman
• hcg; 17-ohp; fertility; spermatogenesis
• Replies: 1
• Forum: hCG, Clomid & Others for Fertility, PCT or Low T

I get soft erections on hcg but before climax i can get erect. I have not been able to understand this conundrum

 

[Nelson Vergel]

Thread 'Behavioral Effects of Neurosteroids Stimulated by hCG in Men on TRT'

Jul 16, 2025

I ran some ChatGPT deep research on the behavioral effects of hCG-derived neurosteroids in men on TRT that you might find interesting.

Behavioral Effects of hCG-Induced Neurosteroids in Men on TRT​

Context: In men undergoing testosterone replacement therapy (TRT), adjunctive human chorionic gonadotropin (hCG) can stimulate the testes to produce not only testosterone but also upstream steroids like pregnenolone, progesterone, and 17-OH-progesterone. This cascade leads to elevated levels of neuroactive steroids (e.g. allopregnanolone and related metabolites) that can cross into...

• FunkOdyssey
• hcg
• Replies: 1
• Forum: When TRT Is Not Enough (ED, Libido, & More)

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