Why don't you try a small dose of Arimidex? Say .125mg... that is an 1/8th of a 1mg tablet. You'll know within a few hours if it helps you. When my E2 is high I feel like I'm depressed and not on testosterone or HCG. I don't feel well at all. And when I'm like that and take .125 of arimidex I feel great within a couple of hours. So if this works then you know you just need to manage your E2 better.