A little background. I was on Clomid for about a month and had a good response but had to stop due to vision side effects. I started my new protocol last week and it is .80mg testestoerone E3.5D, 400IU HCG E3.5D, and .3mg Anastrozole. This was a protocol suggested by Jill at Defy. My E2 had risen on Clomid thus the AI.
I have had episodes of dyspepsia (not sure if that's even the correct term for this) weekly for years and sometimes for days at a time. This isn't just heartburn or GERD. This has been a biliary duct dysfunction and I've even had my gall bladder removed due to poor ejection fraction. Unfortunately, removing my gall bladder didn't really help much, if at all. These attacks cause severe bloating, I cannot belch enough to relieve the pressure in my stomach, and I can literally feel the bile pressure build up and release as the Sphincter of Oddi spasms. It's a really miserable thing and literally nothing but time will make it go away.
After starting Clomid I never had an episode and had not even thought about it...until yesterday. I suspect the two doses of Anastrozole might have crashed E2 because I had a sudden onset of low E2 symptoms...unquenchable thirst, lack of motivation, bloating, anxiety, and an sudden dyspepsia attack.
I realize I'm relying solely on subjective symptoms here and my hormonal state is very much in flux right now. Is it possible only two doses of Anastrozole at .3mg could have had a dramatic E2 lowering effect so soon? Has anyone noted any digestive disturbances when their E2 is less than optimal? I'm just trying to figure out of E2 is in any way related to biliary function.
I have had episodes of dyspepsia (not sure if that's even the correct term for this) weekly for years and sometimes for days at a time. This isn't just heartburn or GERD. This has been a biliary duct dysfunction and I've even had my gall bladder removed due to poor ejection fraction. Unfortunately, removing my gall bladder didn't really help much, if at all. These attacks cause severe bloating, I cannot belch enough to relieve the pressure in my stomach, and I can literally feel the bile pressure build up and release as the Sphincter of Oddi spasms. It's a really miserable thing and literally nothing but time will make it go away.
After starting Clomid I never had an episode and had not even thought about it...until yesterday. I suspect the two doses of Anastrozole might have crashed E2 because I had a sudden onset of low E2 symptoms...unquenchable thirst, lack of motivation, bloating, anxiety, and an sudden dyspepsia attack.
I realize I'm relying solely on subjective symptoms here and my hormonal state is very much in flux right now. Is it possible only two doses of Anastrozole at .3mg could have had a dramatic E2 lowering effect so soon? Has anyone noted any digestive disturbances when their E2 is less than optimal? I'm just trying to figure out of E2 is in any way related to biliary function.
