Does HCG Worsen Secondary Hypogonadism During a Restart?

AJ

New Member
Hello all,

To all the amazing knowledgeable people out here. Please share your knowledge/experience in this matter.
I have heard that people who suffer from secondary hypogonadism and are planning to do HPTA restart should not do HCG as it can potentially make it worse. This is for people who have never used any kind of AAS/TRT/Drugs. I am trying to make sense from theoretical point of view about the 2 type of restart below:

Clomid Only Restart:
4 weeks - Clomid would block estrogen receptors and hence help boost LH and FSH which in turn can boost Test.

Clomid + HCG Restart:
HCG 2 weeks - HCG would help boost Test and E2 conversion. This would probably lower GnrH, LH and FSH as it would think they have enough Test. But HCG would help to boost Test for the 2 weeks.
Then Clomid for 4 weeks - Clomid would block estrogen receptors and hence help boost LH and FSH which in turn can boost Test even more.

Please pardon my gibberish if it didn't make sense. May be someone with far greater knowledge/personal experience can explain this.

P.S: I suffer from secondary hypogonadism. No TRT/AAS in the past. My LH/FSH is normal. T is low around 330. I was prescribed TRT + HCG. But the wonderful people over here told me to try HPTA restart as I am still 33 years old.
 
Hello all,

To all the amazing knowledgeable people out here. Please share your knowledge/experience in this matter.
I have heard that people who suffer from secondary hypogonadism and are planning to do HPTA restart should not do HCG as it can potentially make it worse. This is for people who have never used any kind of AAS/TRT/Drugs. I am trying to make sense from theoretical point of view about the 2 type of restart below:

Clomid Only Restart:
4 weeks - Clomid would block estrogen receptors and hence help boost LH and FSH which in turn can boost Test.

Clomid + HCG Restart:
HCG 2 weeks - HCG would help boost Test and E2 conversion. This would probably lower GnrH, LH and FSH as it would think they have enough Test. But HCG would help to boost Test for the 2 weeks.
Then Clomid for 4 weeks - Clomid would block estrogen receptors and hence help boost LH and FSH which in turn can boost Test even more.

Please pardon my gibberish if it didn't make sense. May be someone with far greater knowledge/personal experience can explain this.

P.S: I suffer from secondary hypogonadism. No TRT/AAS in the past. My LH/FSH is normal. T is low around 330. I was prescribed TRT + HCG. But the wonderful people over here told me to try HPTA restart as I am still 33 years old.

Would like to hear about this also! In the same position as you, 31yo.
 
HCG affects the production of LH. If you do HCG monotherapy you will essentially shut down your own production so if you take it for any length of time it will shut your natural production down. Once you stop HCG you will have to wait for your body to start producing LH on it's own again.
 
HCG is most commonly used during restart to stimulate the testicles prior to the real recovery. There is a short window of time when this is appropriate, but continued HCG will keep LH release shutdown.
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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