DHEA timing?

rhino5169

Member
My RX says take at night. Iv'e seen mostly should take in the AM, but also have read a few times to take at night to help with high cortisol?

What say ye?
 
I've taken it just before bed for years. For some it can have a stimulating effect disrupting sleep in which case 25 mg on the morning and again in the afternoon is ideal.
 
Thanks for the quick reply Gene.
Im also wondering though, is there a benefit to taking at night vs. in the am?
Does it really help offset high cortisol at night, which I have?
 
rhino5169 - Have you taken DHEA before? If not, I'd suggest starting at a considerably lower dose for a few days and see how you respond to it. I was feeling pretty good, but noticed my DHEA labs were low, so I bought ultra micronized DHEA from DHEA.com. Took 25mg one night and felt like garbage the next day. Eventually I got a little relief when cutting my dose down to 12mg. And yet more relief when dropping it to 6mg, before finally feeling much better just days after discontinuing it. I feel much better without it. We're all different, maybe it will help you feel better, just start with a lower dose and be patient (increase dose as symptoms and labs warrant). Sound advice IMO with most anything HRT related. Good luck.
 
Yes, it can help with normalizing the circadian rhythm in the PM, when cortisol imbalances are present. It just all depends where you are at overall with the adrenals? For others and myself it has been immensely beneficial with sleep improvement, but for some it doesn't work so well.
 
I was taking DHEA in the AM and noticed a few hours later I began to feel groggy. I stopped taking DHEA completely and this issue went away. I then read that taking at night may be a better solution for me, tried it and now have zero issues with the DHEA. I am using 25mg that were compounded by pharmacy (Hallandale). Also, since I began taking the DHEA at night (about 2 hours after dinner 7 PM) my sleep has improved. I still seem to have a cortisol spike at 2:30-3:30 AM but the quality of sleep I get is much better. I tend to function pretty well off 6.5 hours sleep per night, would prefer 7.5 but what can you do.
 
I use Pure brand, presently I'm supplementing with 35mg daily. I've tried using it during the day and before bed, it doesn't affect my sleep positive or negatively. I think I'll split my dose like Gene recommended, morning and then again before bed.
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

Beyond Testosterone Podcast

Online statistics

Members online
2
Guests online
370
Total visitors
372

Latest posts

Back
Top