We know that testosterone shuts down natural production. What about PREG? Preg shuts down my natural preg production?Ive been off DHEA for two weeks, off Preg for almost 4 weeks and I feel perfectly fine and using 200iu HCG E3.5D. I do not believe that HCG stims testes (or anything else) to produce DHEA/Preg. DHEA is I believe an Adrenals function. The time I've been using HCG, multiple DHEA-S tests were always lowish but supplementing seems to aggravate my Estrogen. Several of us are now making that correlation with DHEA, though we're low, its making our E very hard to manage.