DHEA Dosing Protocol

Six months ago my DHEA was 66 range 38-313 mcg/dL. Started taking 100mg DHEA at bedtime about 3 months ago. My latest labs came back a couple weeks ago and my DHEA level was 510. My libido is better, mental energy, and my eyes aren't as dry, go figure. I'm going to cut back by alternating 50 and 100mg. Interesting side note, for a week I started taking my DHEA with all my morning supplements. All the benefits seemed to disappear, not sure why? So I'm back taking it right before bed.
 
Six months ago my DHEA was 66 range 38-313 mcg/dL. Started taking 100mg DHEA at bedtime about 3 months ago. My latest labs came back a couple weeks ago and my DHEA level was 510. My libido is better, mental energy, and my eyes aren't as dry, go figure. I'm going to cut back by alternating 50 and 100mg. Interesting side note, for a week I started taking my DHEA with all my morning supplements. All the benefits seemed to disappear, not sure why? So I'm back taking it right before bed.
With hormones you need to be consistent. Alternating 50-100mg doesn’t make much sense
 
Here are my dose-response values using the Natrol brand:
DHEA Dose (mg/d)—Serum DHEA-S (ug/dL)
0—100
0—90
25—480
20—480
12.5—290
12.5—210
12.5—250
12.5—280
12.5—300
12.5—260
 
Here are my dose-response values using the Natrol brand:
DHEA Dose (mg/d)—Serum DHEA-S (ug/dL)
0—100
0—90
25—480
20—480
12.5—290
12.5—210
12.5—250
12.5—280
12.5—300
12.5—260

Interesting, almost my own experience, I think it was an old bottle of DHEA I took at first, 25 mg got me from 25 >450. Now the brand is Natrol, and I elected to do 12.5 +~12.5 mg preg. Though I will check PSA in 20 days and see if any increase. Don't think there should be from DHEA/Preg, but I want to check.
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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