DHEA and Pregnenolone cream vs pill m

munch520

New Member
I have Hashimotos Thyroiditis, along with some low LH/FSH and low free testosterone...I've had two docs with two different schools of thought address the LH/FSH and low free T (total T is great).

Doc 1: Prescribed oral DHEA and Pregnenolone. The DHEA came from an off book pharmacy (can't remember dose), the Preg is 10mg/pill from Pure Encapsulations.
Doc 2: Says that taking these orally is stupid, the dosage is millions of times higher than the body needs, so he says the liver will react to this influx of hormone by creating more SHBG, further lowering my free T levels. He says a cream (or basically anything other than oral) is much better, as the skin absorbs in much smaller concentrations, and this will avoid the reaction from the liver. This will allow the hormones to do their job, without any adverse affects on free T.

Approach #2 makes sense to me, anyone else compared the two delivery methods? What were your experiences? Should I also be considering sublingual?

Thanks in advance!
 
Last edited:
There can be interaction in the liver where DHEA can aromatase, TD is preferred, but the oral micro-nized versions of both pro-hormones are most likely to survive first pass thru the liver. I haven't seen a dosing difference in the capsules and TD.
 
OK thanks I will look into that and the sublingual. The latter is substantially cheaper than the cream and I would think dosage would be more stable going that route...
 
Oral absorbtion I'm told has varied a lot from person to person.
I can take anything off the shelf orally and get great results and never had an effect on shbg. Sublingual is also a great method.
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

Beyond Testosterone Podcast

Online statistics

Members online
1
Guests online
490
Total visitors
491

Latest posts

Back
Top