Detailed Labs of 42yr old healthy with some recent sexual symptoms

Are there blood tests that measure levels of the 5α-reductase enzyme and the Aromatase enzyme directly?

I have lower end Free T but have upper end DHT and am wondering if it is because my body is producing too much 5α-reductase enzyme?
 
I have lower end Free T but have upper end DHT and am wondering if it is because my body is producing too much 5α-reductase enzyme?
It wouldn't be too dissimilar to someone with high levels of aromatase enzymes who over converts to estrogen.
Are there blood tests that measure levels of the 5α-reductase enzyme and the Aromatase enzyme directly?
I have only heard of testing DHT. I have never heard of be able to test an enzyme and don't know why anyone would want to because it doesn't change treatment plans.
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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