Damage to my penis... please help

[sileebo]

Hi guys.. I've had ED for years. I was prescribed trimix and misused it by injecting myself multiple times in one session which I know was extremely stupid but I was desperate cuz I couldnt find my dosage and didnt want to disappoint my gf. This happened in May last month. I shouldve tested it to find my dosage before having sex, I know.

That said, as a result of this, my penis has become highly sensitive to the touch on the right side and head. In 2 months I'll be traveling to see my gf again and want to be able to get erect since I plan to marry her.

I looked into PRP, PRFM and exosomes which I'm hoping will repair what happened to my penis. Please let me know what are good clinics that offer these and at hopefully affordable prices.

Looking forward!!

 

[Nelson Vergel]

Unfortunately, I would just take ibuprofen daily and try not to masturbate or have sex. Your penis needs rest.

Some urologists, like Dr. Lipshults, recommend these to minimize penile fibrosis. There are no good studies to prove they are effective.

Over-the-Counter (OTC) Supplements and Prescription Drugs Urologists Recommend for Minimizing Penile Fibrosis
Penile fibrosis, most commonly associated with Peyronie’s disease, involves the development of fibrous plaques in the penile tissue, leading to curvature, pain, and sometimes erectile dysfunction. While prescription medications and procedures are the mainstays of treatment, several OTC supplements are commonly discussed in urology for their potential to minimize fibrosis or slow disease progression. The evidence for these supplements varies, and they are generally considered adjuncts rather than primary therapies.
Commonly Recommended OTC Supplements
· Vitamin E
o One of the most widely used supplements for Peyronie’s disease due to its antioxidant properties. It is thought to help reduce oxidative stress and possibly minimize plaque formation, although robust clinical evidence is limited and guidelines do not strongly recommend it as monotherapy[1][2][3][4].
· Acetyl-L-Carnitine
o Some studies suggest acetyl-L-carnitine may reduce pain and slow curvature progression, possibly due to its anti-inflammatory and antioxidant effects. It may be particularly effective in the early, painful phase of the disease[1][5][2].
· Coenzyme Q10 (CoQ10)
o CoQ10 has shown promise in reducing plaque size and improving erectile function in some studies, likely due to its role in cellular energy production and antioxidant activity[5][2].
· Omega-3 Fatty Acids
o Known for their anti-inflammatory properties, omega-3s may help reduce inflammation and support tissue health, though direct evidence for their effect on penile fibrosis is limited[2][3][4].
· L-Arginine
o An amino acid precursor to nitric oxide, L-arginine may help by promoting vasodilation and supporting tissue health. Animal studies suggest it could reduce plaque size and collagen deposition, especially when used in combination with other therapies[1][6][3][7].
· Curcumin
o Derived from turmeric, curcumin has demonstrated antifibrotic, anti-inflammatory, and antioxidant properties in animal models. One study in rats showed curcumin reduced fibrotic tissue in the tunica albuginea, suggesting potential benefit, though human data are lacking[8].
Supplements with Prescription-Only or Limited OTC Access
· Potassium Para-Aminobenzoate (POTABA)
o POTABA is a B-complex vitamin derivative that inhibits fibroblast activity. It has shown some benefit in reducing curvature and plaque in clinical studies, but it is available by prescription only in the US[1][9][6].
· Pentoxifylline
o An oral medication with anti-inflammatory and antifibrotic effects, pentoxifylline is sometimes compounded and used off-label for Peyronie’s disease. It is not typically available OTC[3].
Summary Table

Supplement	Evidence in Penile Fibrosis	Mechanism	OTC Status
Vitamin E	Weak/controversial	Antioxidant	Yes
Acetyl-L-carnitine	Some supportive studies	Anti-inflammatory/antioxidant	Yes
CoQ10	Some supportive studies	Antioxidant, cellular health	Yes
Omega-3	Weak/controversial	Anti-inflammatory	Yes
L-Arginine	Animal/basic science data	Nitric oxide precursor	Yes
Curcumin	Animal data	Antifibrotic/antioxidant	Yes
POTABA	Human studies	Antifibrotic	Prescription
Pentoxifylline	Human studies	Antifibrotic	Prescription

Guideline Perspective and Clinical Advice
· The American Urological Association (AUA) does not currently recommend any oral OTC supplement as a first-line or proven therapy for penile fibrosis or Peyronie’s disease due to insufficient high-quality evidence[10][4].
· Supplements may be considered as adjuncts for men seeking non-invasive options, particularly in early or mild disease, but should not replace guideline-supported treatments.
· Always consult a healthcare professional before starting any supplement, as interactions and side effects are possible, and some supplements may interfere with other medications or conditions[2][7].
"Supplements like Vitamin E, CoQ10, and omega-3s can play a valuable role in managing Peyronie’s disease. By integrating the best supplements for Peyronie’s disease into a comprehensive treatment plan, men can support their recovery and enhance their quality of life naturally. Always consult with a healthcare provider before starting any supplement regimen to ensure safety and effectiveness."[2]
In summary: Urologists may discuss OTC supplements such as vitamin E, acetyl-L-carnitine, CoQ10, omega-3 fatty acids, L-arginine, and curcumin for their potential to minimize penile fibrosis, but robust clinical evidence is lacking and these should be considered adjunctive to standard medical care[1][2][3][4].

​

1. https://pmc.ncbi.nlm.nih.gov/articles/PMC7108992/
2. https://www.andrologyexcellence.com/post/best-supplements-for-peyronie-s-disease-a-natural-approach-to-support-healing
3. https://lowcountrymale.com/best-supplements-peyronies-disease/
4. https://tau.amegroups.org/article/view/10425/html
5. https://www.webmd.com/vitamins/condition-1474/peyronie-disease
6. https://tau.amegroups.org/article/view/28824/html
7. https://www.goodrx.com/conditions/erectile-dysfunction/viagra-alternatives
8. https://grandjournalofurology.com/text.php?id=93
9. https://www.urophoenix.com/2022/11/22/oral-medications-that-can-help-with-peyronies-disease/

10. https://www.auanet.org/guidelines-and-quality/guidelines/peyronies-disease-guideline

 

[Guided_by_Voices]

This is just a wild guess on my part, but a vacuum penis pump might be worth a try. The concept would be that it draws blood into the penis and the increased blood flow might be therapeutic. There was also a study posted here a while back that said Hyperbaric Oxygen Therapy increased vascular health of the penis. There are an increasing number of clinics that offer at least the low pressure version and you might be able to get a prescription for the high pressure version, or go to a clinic that offers Exercise With Oxygen Therapy, which might be even better. Good luck to you.