Cypionate vs Propionate for daily injections

The ester form of T is a prohormone and is inert, in the end what is released after the esterase acts on the ester is testosterone, the active form. The ester simply dictates the rate of release of the active hormone. Prop will give you a shorter duration of action but higher blood concentration or spike after an inj relative to the same dose of cyp or enanthate. Sometimes I think half of what guys/women feel is what they think is going to happen. For example people think they can tell the difference between cyp and enanthate. The blood conc after the same dose of each is the same over time. I'll bet if we did a study that double blinded the shots, most that think they can tell a difference couldn't given the same oil carrier and preservative/conc.

Ugh, I wish there were places that cared about carrying out studies in regards to HRT like this. Sucks in a way that there’s no money for big pharma to make off of HRT. If there was, I’m sure we’d have much more studies like the one ur asking for

But there’s definitely a lot more in play than we think, when it comes to esters. I personally can’t explain all the reasons that they have differing effects, but I’ve seen enough examples and anecdotes over the past decade plus of researching and being in the HRT game to know that the ester has more of an effect than we think. I can speculate and theorize why, but would love more scientific and exact answers one day
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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