Cypionate and Synthroid

[WDE94]

Been on cypionate for about 7 months now, levels are good. Just did TSH with different doctor and my level was a lot higher than previously and been on same dosage of synthroid for last few years. Question is,does cypionate affect synthroid medication? TSH level usually around 1.51 and was 7.9 today. Any information is greatly appreciated.

 

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Sex steroids and the thyroid

Thyroid function is modulated by genetic and environmental causes as well as other illnesses and medications such as gonadal or sex steroids. The latt…

www.sciencedirect.com

 

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https://eje.bioscientifica.com/downloadpdf/journals/eje/155/1/1550011.pdf

 

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https://onlinelibrary.wiley.com/doi/epdf/10.1111/and.12862

 

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Frontiers | Homeostatic Control of the Thyroid–Pituitary Axis: Perspectives for Diagnosis and Treatment

The long-held concept of a proportional negative feedback control between the thyroid and pituitary gland requires reconsideration in the light of more recen...

www.frontiersin.org

 

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Population data indicate that thyroid regulation is consistent with an equilibrium-point model, but not with a set-point model

Published in Temperature (Vol. 4, No. 2, 2017)

www.tandfonline.com

 

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Redefinition of Successful Treatment of Patients With Hypothyroidism. Is TSH the Best Biomarker of Euthyroidism? - PMC

In recent years evidence has accumulated supporting a revised view of the nature of euthyroidism and the biomarkers of thyroid function. Within the normal range, variations in thyroid hormone levels are associated with variations in clinical ...

www.ncbi.nlm.nih.gov

 

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Physiological linkage of thyroid and pituitary sensitivities - Endocrine

Objectives The sensitivities of the pituitary to thyroxine feedback, and the thyroid to thyrotropin stimulation determine the free thyroxine /thyrotropin feedback loop and can be described mathematically by two curves. It is not well understood how the two curves combine in a healthy population...

link.springer.com

Excellent review with latest population data assessment.

 

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I’m confused about 1 thing in this section. It says in the beginning that after treatment with fluoxymestrone, the hypothyroid patients TT4 and TBG decreased. But then later on, it said that the FT4 levels increased and TSH decreased, thereby lowering the patients thyroid hormone requirements. These two statements sound contradictory to me. They seem to say the complete opposite of each other. Can someone explain what I’m missing?

TBG controls Total T4. Depending on TBG drop, fT4 can go up while Total T4 mirrors TBG. Added the graphs for you. TSH would titrate to fT4/fT3 levels according to setpoint theory.

 

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Question is,does cypionate affect synthroid medication? TSH level usually around 1.51 and was 7.9 today. Any information is greatly appreciated.

Hope the above helps show your question is a challenging one. Mixing TRT with thyroid autoimmunity/hypothroidism is a fun science project. Been chasing my thyroid parameters for many years. TRT only made the project much more challenging since it makes the thyroid axis work harder and with a failing thyroid that makes for lots of "fun".

 

[raw91]

Hope the above helps show your question is a challenging one. Mixing TRT with thyroid autoimmunity/hypothroidism is a fun science project. Been chasing my thyroid parameters for many years. TRT only made the project much more challenging since it makes the thyroid axis work harder and with a failing thyroid that makes for lots of "fun".

Sounds just like me. I usually take 150mcg of t4 while on 150-175mg test/week. Daily injections, no AI or other stuff with the test. Sometimes I do a cycle of like 500mg test for a few weeks.

I always find I become hypterthyroid when I raise the test dose, probably according to lowering of TBG. This happens pretty fast, usually on the first week of cycle.

Do you need to alter your dose of t4 with higher testosterone too?