Curing PSSD (low E2 Symptoms)

[steve4422]

Hello, I suffer from a iatrogenic condition called PSSD (Post SSRI Sexual Dysfunction) for 5 years now, people think that this is caused by low androgen and estrogen receptor signalling. I have severe cognitive decline and sexual issues.

Do you have any idea what can help with this condition and how to unsilence the downregulated estrogen receptors? I had a few ideas:

1) Tamoxifen could upregulate ERa
2) Tren or other Progestins can upregulate ER
3) TRT+HCG+Soy Isoflavones
4) Vorinostat

My brain is absolutely fogged to the max and I can barely type here. I managed to get moclobemide which could reverse some of the cognitive issues WHILE taking it at least but it is no cure. Vorinostat was shown to upregulate estrogen receptor alpha in breast cancer cell lines, this could restore the ER signalling in PSSD and is my best bet atm. However maybe something like TRT+HCG+Soy Isoflavones could fix this too

 

[Kenp]

I feel your pain friend, PFS here.

Check last pages of this thread, full of recoveries and potential regimens: Finally Cured From Post Finasteride Syndrome

 

[steve4422]

I feel your pain friend, PFS here.

Check last pages of this thread, full of recoveries and potential regimens: Finally Cured From Post Finasteride Syndrome

What would you try out of above stacks? anything new?

 

[Kenp]

What would you try out of above stacks? anything new?

If I was you I'd try enclomi phene for a few months first. If not then I'd try HCG. Then HCG + TRT + DHT derivative (like masteron or proviron) + a HDACI (like vorinostat or maybe "safer" ones first like sulforaphane). If that doesn't work I'd end with Test gel + DHT gel regimen as a last hormonal try.

If you don't feel any improvements from these hormonal treatments then I'd try things like Modafinil and look more into neurological regimens.

It's all trial and error in the end sadly.

 

[steve4422]

If I was you I'd try enclomi phene for a few months first. If not then I'd try HCG. Then HCG + TRT + DHT derivative (like masteron or proviron) + a HDACI (like vorinostat or maybe "safer" ones first like sulforaphane). If that doesn't work I'd end with Test gel + DHT gel regimen as a last hormonal try.

If you don't feel any improvements from these hormonal treatments then I'd try things like Modafinil and look more into neurological regimens.

It's all trial and error in the end sadly.

Why Enclomiphene?

I have liposomal sulforaphane here. im currently on TRT

What about soy isoflavones? Modafinil works abit. Dexamphatmine is better. Trying moclobemide rn.

 

[Forty2]

Hello, I suffer from a iatrogenic condition called PSSD (Post SSRI Sexual Dysfunction) for 5 years now, people think that this is caused by low androgen and estrogen receptor signalling. I have severe cognitive decline and sexual issues.

Do you have any idea what can help with this condition and how to unsilence the downregulated estrogen receptors? I had a few ideas:

1) Tamoxifen could upregulate ERa
2) Tren or other Progestins can upregulate ER
3) TRT+HCG+Soy Isoflavones
4) Vorinostat

My brain is absolutely fogged to the max and I can barely type here. I managed to get moclobemide which could reverse some of the cognitive issues WHILE taking it at least but it is no cure. Vorinostat was shown to upregulate estrogen receptor alpha in breast cancer cell lines, this could restore the ER signalling in PSSD and is my best bet atm. However maybe something like TRT+HCG+Soy Isoflavones could fix this too

I'm in the same boat. I also have post Accutane syndrome, so the "double wammy".
My main issue is poor sensation/DE in addition to low libido.
Enclomiphene and tamoxifen made things a lot worse for me. The only positive was better energy. Urinary derived hCG, not compounded hCG is what worked the best for me. The only form of testosterone I've tried so far is enanthate which worsened sensation and caused ED which I didn't have prior.

 

[Jerajera]

What makes you think it's E2 and not androgen signaling? What have you tried already?

You should check out a guy with a chanel named Cortex Labs on youtube. He's selling stuff but he's relatively smart and knows a lot more than most people in this space.

I would definitely try some combination of Test + hCG + DHT (actual DHT, not a DHT derivative. So either DHT gel or injectable DHT).

If you're not already set up with a doctor for this and want to move fast, your best bet would be to go UGL. Also because DHT is not prescribable in the US. If you look around it's really not hard to find stuff, you'll figure it out quickly.

If you need an actual protocol to get you started I'd start low and go up from there. Start with 15mg/day Test E, 50iu/day hCG. Give it at least 8 weeks if you've never taken Test or anything that legit shuts down your HPGA because it's going to take time for your system to adapt to being shut down and then hormone replacement/optimization.

From there, slowly up the Test and hCG if you're still not feeling any progress, and use DHT to shift your hormone balance to a more androgenic state and antagonize E2 if you're overaromatizing, which you almost certainly will with PSSD/Fin syndrome.

From what I've seen, most guys on Fin/PSSD, etc...forums have no idea what they're doing and focus on the wrong stuff. This is almost certainly hormone related and that's probably the only way to fix it.

Don't overthink it unless you want to still be browsing forums in 5 years having made no progress.

 

[Kenp]

From what I've seen, most guys on Fin/PSSD, etc...forums have no idea what they're doing and focus on the wrong stuff. This is almost certainly hormone related and that's probably the only way to fix it.

Don't overthink it unless you want to still be browsing forums in 5 years having made no progress.

Sadly it's not that easy though. Also many people that did tons of hormonal regimens and didn't get better. I do agree with using actual DHT (like gel) instead of DHT derivatives.

 

[steve4422]

What makes you think it's E2 and not androgen signaling? What have you tried already?

You should check out a guy with a chanel named Cortex Labs on youtube. He's selling stuff but he's relatively smart and knows a lot more than most people in this space.

I would definitely try some combination of Test + hCG + DHT (actual DHT, not a DHT derivative. So either DHT gel or injectable DHT).

If you're not already set up with a doctor for this and want to move fast, your best bet would be to go UGL. Also because DHT is not prescribable in the US. If you look around it's really not hard to find stuff, you'll figure it out quickly.

If you need an actual protocol to get you started I'd start low and go up from there. Start with 15mg/day Test E, 50iu/day hCG. Give it at least 8 weeks if you've never taken Test or anything that legit shuts down your HPGA because it's going to take time for your system to adapt to being shut down and then hormone replacement/optimization.

From there, slowly up the Test and hCG if you're still not feeling any progress, and use DHT to shift your hormone balance to a more androgenic state and antagonize E2 if you're overaromatizing, which you almost certainly will with PSSD/Fin syndrome.

From what I've seen, most guys on Fin/PSSD, etc...forums have no idea what they're doing and focus on the wrong stuff. This is almost certainly hormone related and that's probably the only way to fix it.

Don't overthink it unless you want to still be browsing forums in 5 years having made no progress.

Its because I dont just have sexual issues but also cognitive impairment. Im thinking about doing a vorinostat group buy and solve it in DMSO and take it above 200mg a day. It should unsilence both the androgen and estrogen receptor

I agree that its hormone related but blasting androgens does nothing to me, with ER downregulation the AR is downregulated too unfortunately, i ran 500mg trt + 30mg tren EOD and nothing, my AR is silenced to the max

 

[Kenp]

Its because I dont just have sexual issues but also cognitive impairment. Im thinking about doing a vorinostat group buy and solve it in DMSO and take it above 200mg a day. It should unsilence both the androgen and estrogen receptor

I agree that its hormone related but blasting androgens does nothing to me, with ER downregulation the AR is downregulated too unfortunately, i ran 500mg trt + 30mg tren EOD and nothing, my AR is silenced to the max

Could work. Although I read you need to combine a HDACI like vorinistat with androgens (DHT gel would be a good choice)

 

[steve4422]

Could work. Although I read you need to combine a HDACI like vorinistat with androgens (DHT gel would be a good choice)

Where did you read this? I read so too, tho.

 

[Kenp]

Where did you read this? I read so too, tho.

The thread I linked

 

[steve4422]

The thread I linked

I'm trying to get more information on HDACis and which ones to use, right now im using EGCG+Sulforaphane but i wanna go for decitabine+vorinostat if its not enough

 

[Kenp]

I'm trying to get more information on HDACis and which ones to use, right now im using EGCG+Sulforaphane but i wanna go for decitabine+vorinostat if its not enough

Check Mister's post about hdaci's here: Finally Cured From Post Finasteride Syndrome

 

[steve4422]

Check Mister's post about hdaci's here: Finally Cured From Post Finasteride Syndrome

Thank you - sulforaphane looks good but for me didnt really move the needle. im thinking about vorinostat

 

[Kenp]

Thank you - sulforaphane looks good but for me didnt really move the needle. im thinking about vorinostat

Sounds good if you can get it

 

[steve4422]

Sounds good if you can get it

I have it here already, can you suggest other methods to increase E2 signalling? I have soy isoflavone here and i even thought about using ibogaine.

 

[Kenp]

I have it here already, can you suggest other methods to increase E2 signalling? I have soy isoflavone here and i even thought about using ibogaine.

I don't understand why you'd increase E2 singalling though? I'm not familiar with that theory..

 

[steve4422]

I don't understand why you'd increase E2 singalling though? I'm not familiar with that theory..

Because SSRIs silenced my E2 receptors in theory (low e2 signal)

 

[steve4422]

I have it here already, can you suggest other methods to increase E2 signalling? I have soy isoflavone here and i even thought about using ibogaine.

Also thought about using raloxifene.