Curing PSSD (low E2 Symptoms)

[steve4422]

Hello, I suffer from a iatrogenic condition called PSSD (Post SSRI Sexual Dysfunction) for 5 years now, people think that this is caused by low androgen and estrogen receptor signalling. I have severe cognitive decline and sexual issues.

Do you have any idea what can help with this condition and how to unsilence the downregulated estrogen receptors? I had a few ideas:

1) Tamoxifen could upregulate ERa
2) Tren or other Progestins can upregulate ER
3) TRT+HCG+Soy Isoflavones
4) Vorinostat

My brain is absolutely fogged to the max and I can barely type here. I managed to get moclobemide which could reverse some of the cognitive issues WHILE taking it at least but it is no cure. Vorinostat was shown to upregulate estrogen receptor alpha in breast cancer cell lines, this could restore the ER signalling in PSSD and is my best bet atm. However maybe something like TRT+HCG+Soy Isoflavones could fix this too

 

[Kenp]

I feel your pain friend, PFS here.

Check last pages of this thread, full of recoveries and potential regimens: Finally Cured From Post Finasteride Syndrome

 

[steve4422]

I feel your pain friend, PFS here.

Check last pages of this thread, full of recoveries and potential regimens: Finally Cured From Post Finasteride Syndrome

What would you try out of above stacks? anything new?

 

[Kenp]

What would you try out of above stacks? anything new?

If I was you I'd try enclomi phene for a few months first. If not then I'd try HCG. Then HCG + TRT + DHT derivative (like masteron or proviron) + a HDACI (like vorinostat or maybe "safer" ones first like sulforaphane). If that doesn't work I'd end with Test gel + DHT gel regimen as a last hormonal try.

If you don't feel any improvements from these hormonal treatments then I'd try things like Modafinil and look more into neurological regimens.

It's all trial and error in the end sadly.

 

[steve4422]

If I was you I'd try enclomi phene for a few months first. If not then I'd try HCG. Then HCG + TRT + DHT derivative (like masteron or proviron) + a HDACI (like vorinostat or maybe "safer" ones first like sulforaphane). If that doesn't work I'd end with Test gel + DHT gel regimen as a last hormonal try.

If you don't feel any improvements from these hormonal treatments then I'd try things like Modafinil and look more into neurological regimens.

It's all trial and error in the end sadly.

Why Enclomiphene?

I have liposomal sulforaphane here. im currently on TRT

What about soy isoflavones? Modafinil works abit. Dexamphatmine is better. Trying moclobemide rn.