Hello, I suffer from a iatrogenic condition called PSSD (Post SSRI Sexual Dysfunction) for 5 years now, people think that this is caused by low androgen and estrogen receptor signalling. I have severe cognitive decline and sexual issues.
Do you have any idea what can help with this condition and how to unsilence the downregulated estrogen receptors? I had a few ideas:
1) Tamoxifen could upregulate ERa
2) Tren or other Progestins can upregulate ER
3) TRT+HCG+Soy Isoflavones
4) Vorinostat
My brain is absolutely fogged to the max and I can barely type here. I managed to get moclobemide which could reverse some of the cognitive issues WHILE taking it at least but it is no cure. Vorinostat was shown to upregulate estrogen receptor alpha in breast cancer cell lines, this could restore the ER signalling in PSSD and is my best bet atm. However maybe something like TRT+HCG+Soy Isoflavones could fix this too
Do you have any idea what can help with this condition and how to unsilence the downregulated estrogen receptors? I had a few ideas:
1) Tamoxifen could upregulate ERa
2) Tren or other Progestins can upregulate ER
3) TRT+HCG+Soy Isoflavones
4) Vorinostat
My brain is absolutely fogged to the max and I can barely type here. I managed to get moclobemide which could reverse some of the cognitive issues WHILE taking it at least but it is no cure. Vorinostat was shown to upregulate estrogen receptor alpha in breast cancer cell lines, this could restore the ER signalling in PSSD and is my best bet atm. However maybe something like TRT+HCG+Soy Isoflavones could fix this too