Creatine for brain health and function

madman

Super Moderator
Creatine supplementation shows potential benefits for brain health and function, particularly in aging adults and during metabolic stress. It improves cognition, memory, and health outcomes associated with conditions like muscular dystrophy, traumatic brain injury, depression, and anxiety. However, the impact of creatine on brain health and function in relation to sex and age is not well understood. This review aims to provide an up-to-date summary of the research on creatine's effects on brain health and function. It also explores potential sex and age differences in the response to creatine supplementation, including brain bioenergetics and neurological diseases.



Key points:
  • Creatine supplementation can increase brain creatine content, potentially benefiting brain health and function
  • It has shown positive effects on measures of cognition and memory, particularly in aging adults
  • Creatine supplementation may improve symptoms of sleep deprivation in both humans and animals
  • It shows promise in alleviating symptoms of traumatic brain injury (TBI) and muscular dystrophy
  • The effects of creatine on depression and anxiety are encouraging, but more clinical trials are needed
  • Future research is required to understand the long-term dosing strategies and effects of creatine supplementation on brain function and health
  • The existence of sex- and age-related differences in response to creatine supplementation is still not fully determined
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

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The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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