In this episode, Dr. Brandon and Dr. Morgentaler talk about how emerging research suggests testosterone therapy may not only be safe but could actually help protect against aggressive prostate cancer, while also touching on practical approaches to maintaining sexual connection at midlife.
00:34 Addressing Listener Questions on Sexual Connection – Dr. Brandon and Dr. Morgentaler discuss practical, therapist-friendly strategies for couples looking to gently reboot intimacy and improve sexual connection at midlife.
04:17 Introduction to Testosterone and Prostate Cancer – The hosts introduce the question of whether testosterone therapy could be protective against prostate cancer, setting the stage for reviewing the latest evidence.
05:06 Historical Perspective on Testosterone Therapy – They review the decades-long belief that testosterone increases prostate cancer risk and explain how this view limited therapy use until more recent decades.
08:15 Recent Research and Findings – They highlight large observational studies and randomized trials showing that testosterone therapy is not linked to higher prostate cancer risk and may even reduce aggressive cancer incidence.
16:26 Concluding Thoughts and Future Directions – The hosts emphasize the need for future randomized trials and discuss how these findings are shifting perspectives on testosterone therapy for men’s health.
* one of the things that the orals have transformed is the concept that you have to have a continually high level of testosterone to get the benefits and clearly that's not true and the safety profile seems to be improved by having levels that fluctuate some during the day returning to close to or even baseline
Synopsis
Dr. Morgentaler starts by sharing his pioneering journey with testosterone...
* Gaps in long-term data and areas for further research are identified, underscoring the need for careful application in clinical practice. This paper emphasises a multidisciplinary approach in patient selection, rigorous monitoring protocols, and fully informed decision-making. By presenting a comprehensive review of the evidence, we aim to clarify the role of TRT in improving quality of life for men in remission from prostate cancer, while ensuring that oncological safety remains the highest priority.
Table 1 Comparison of TRT Guidelines from BSSM, AUA, and EAU...
Testosterone Treatment and the Risk of Prostate Adverse Events (2022) Jason A. Levy, DO, MS, Arthur L. Burnett, MD, MBA, Adrian S. Dobs, MD, MHS
INTRODUCTION
Definition Hypogonadism is a clinical syndrome that results from failure of the testis to produce physiologic concentrations of testosterone (T).1 Various thresholds exist to define low total T ranging from 230 to 350 ng/dL. Peak T levels typically are measured between 3 and 8 AM with total T level decreasing during the first 30 minutes of waking.2Serum T decreases with age and has shown to have an...
* debunk the long-standing myth that testosterone fuels prostate cancer
In this episode, Dr. Geo interviews Dr. Helen Bernie from Indiana University about Testosterone Replacement Therapy (TRT) post-prostate cancer diagnosis and treatment. They discuss the suitability of TRT for different stages of prostate cancer patients, debunk the long-standing myth that testosterone fuels prostate cancer, and highlight the importance of a shared decision-making process for improving patient...
Predict estradiol, DHT, and free testosterone levels based on total testosterone
⚠️ Medical Disclaimer
This tool provides predictions based on statistical models and should NOT replace professional medical advice.
Always consult with your healthcare provider before making any changes to your TRT protocol.
ℹ️ Input Parameters
Normal range: 300-1000 ng/dL
Predicted Hormone Levels
Enter your total testosterone value to see predictions
Results will appear here after calculation
Understanding Your Hormones
Estradiol (E2)
A form of estrogen produced from testosterone. Important for bone health, mood, and libido.
Too high can cause side effects; too low can affect well-being.
DHT
Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth,
prostate health, and masculinization effects.
Free Testosterone
The biologically active form of testosterone not bound to proteins.
Directly available for cellular uptake and biological effects.
Scientific Reference
Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.
