Clomiphene and Enclomiphene

 

 

 

 

 

 

 

 

 

 

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INTRODUCING GREG McKETTRICK, RPhGreg McKettrick is a compounding pharmacist in Charlotte, NC. He is a graduate of Wayne State University in Detroit, MI. and has over 30 years of experience as a pharmacist.

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Enclomiphene restart - how long? - Excel Male Men's Health Forum

38M who has been on TRT + HCG for ~5 years or so. I wanted to see if I could restart production with the help of enclomiphene, as prior to TRT I had a great response to clomid but could not handle the estrogen related sides. I started 12.5mg ED about a month ago, and just got back labs from a...

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post #7 Go nuts!

Clomiphene citrate: A potential alternative for TRT in men with low testosterone - Excel Male Men's Health Forum

Clomiphene citrate: A potential alternative for testosterone therapy in hypogonadal males (2023) M. Huijben | M. T. W. T. Lock | V. F. de Kemp | J. J. H. Beck | L. M. O. De Kort | H. M. K. van Breda Abstract Background Hypogonadism is a worldwide problem among men causing sexual, physical...

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Safety and Efficacy of Enclomiphene Compared to Clomiphene in Men with Low Testosterone - Excel Male TRT Forum

*Our findings show that enclomiphene provides the same magnitude of improvement in testosterone but through safer means, as noted by its lower rate of documented adverse events *Further research and larger studies are warranted to validate these conclusions and explore additional long-term...

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We have seen that HCG alone can increase sperm counts, and the claim that HCG has less impact on estrogen than TRT is pretty wild.

 

View attachment 43569
We have seen that HCG alone can increase sperm counts, and the claim that HCG has less impact on estrogen than TRT is pretty wild.

He needs to renege on that one!

Even then keep in mind that when it come to the quality/quantity of sperm the addition of FSH is needed.

The combination of hCG + FSH is more effective overall!

This is key:

*Due to residual FSH secretion, spermatogenesis can be begun with hCG alone in most individuals with bigger testes at baseline

*normal qualitative and quantitative sperm production is best maintained in the presence of both FSH- and LH-induced testosterone secretion

*In addition to maintaining ITT levels with hCG, some men will require Sertoli cell stimulation with FSH

HMG (Human Menopausal Gonadotropin) Vrs HCG (Human Chorionic Gonadotropin) - What’s the difference? - Excel Male Men's Health Forum

I was just watching a video on YouTube titled: ”The Pro's & Con's Of HCG On Cycle | Desensitisation | Testicular Volume | Semen Volume | Fertility”. Video Link The speaker who appears to understand the subject much better than I do introduced HMG (Human Menopausal Gonadotrophin)...

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*normal qualitative and quantitative sperm production is best maintained in the presence of both FSH- and LH-induced testosterone secretion. Human chorionic gonadotrophin (hCG) in conjunction with FSH is a common regimen for inducing spermatogenesis

*Typically, hCG alone at a dose of 1000 IU on alternate days or twice weekly is usually used to start gonadotrophin therapy, with the dose titrated based on trough testosterone levels and testicular development

*Due to residual FSH secretion, spermatogenesis can be begun with hCG alone in most individuals with bigger testes at baseline

*Once there is a plateau in the response to hCG, which typically occurs at around 6 months, therapy with FSH (in one of the three forms described above) should be added at a dose of 75 IU on 3 days per week. If sperm output and testicular growth remain suboptimal, the dose of FSH can be gradually increased to 150 IU daily

 

I never got the concept of first using HCG alone for months before adding FSH, if it's available you'd think one would like the surest fastest way to fertility.

 

I never got the concept of first using HCG alone for months before adding FSH, if it's available you'd think one would like the surest fastest way to fertility.

Comes down to the cost as FSH is expensive.

When it comes to fertility the gold standard would be hCG + rFSH as they work synergistically.


*Spermatogenesis is largely dependent on the action of FSH on Sertoli cells coupled with high intra-testicular testosterone concentrations. Within the seminiferous tubules, only Sertoli cells possess receptors for both FSH and testosterone. Numerous signaling pathways are activated when FSH binds to FSH receptors on these cells. It acts synergistically with testosterone to increase fertility and the efficiency of spermatogenesis

 

Clomiphene vs Enclomiphene

Are there significant difference between Clomiphene citrate and Enclomiphene citrate to warrant using one over the other? I will explain some of the Pros and Cons of each and then discuss our outcome experiences and side-effects in over 800+ clients. I address our 2014, three-year clinical...

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Thread 'CYP2D6 Genetic Variants Influence Hormonal and Spermatic Responses to Enclomiphene in Male Infertility Therapy'

Apr 11, 2025

* Univariate analysis showed that poor metabolizers had the greatest improvements in luteinizing hormone (LH), follicle-stimulating hormone (FSH), and sperm concentration (Figures 1 and 2, p<0.05). There was no statistical difference in testosterone level. Multivariate linear regression indicated that age, clomiphene vs enclomiphene use, baseline hormone levels and sperm concentration were not associated with response (p>0.05), however, metabolizer status significantly predicted increases in LH, FSH, and sperm concentration (p<0.05).


* Infertile...

• madman
• hypogonadism; clomid/enclomiphene; adverse events
• Replies: 0
• Forum: hCG, Clomid & Others for Fertility, PCT or Low T