Cardiometabolic Health: Do Sex Steroids Matter?

[madman]

What about testosterone?

Testosterone blood levels do not significantly change at menopause

In women, testosterone declines to a nadir, then gradually increases

Endogenous testosterone in post menopause women aged 40-70 years*

Testosterone improves endothelium dependent and independent function in postmenopausal women on concurrent estradiol

Systolic blood pressure falls acutely after a single dose of inhaled testosterone

 

[madman]

RCTs of testosterone in women aged 40-70y over 12m

 

[madman]

Serum testosterone increase ~ 11% from age 70-94 years, n=5326

LOW testosterone associated with a 2-FOLD risk of ischemic MACE*

Women aged ≥ 70 years: HIGHER testosterone associated with LESS androgenic profile

 

[madman]

SUMMARY

Testosterone in women:

 

[madman]

Sex-chromosomes influence CVD risk. independent of sex hormones

Menopause MAPS ONTO each woman's pre-existing risk

 

[madman]

Conclusions