Cardiometabolic Health: Do Sex Steroids Matter?

[madman]

What about testosterone?

Testosterone blood levels do not significantly change at menopause

In women, testosterone declines to a nadir, then gradually increases

Endogenous testosterone in post menopause women aged 40-70 years*

Testosterone improves endothelium dependent and independent function in postmenopausal women on concurrent estradiol

Systolic blood pressure falls acutely after a single dose of inhaled testosterone

 

[madman]

RCTs of testosterone in women aged 40-70y over 12m

 

[madman]

Serum testosterone increase ~ 11% from age 70-94 years, n=5326

LOW testosterone associated with a 2-FOLD risk of ischemic MACE*

Women aged ≥ 70 years: HIGHER testosterone associated with LESS androgenic profile

 

[madman]

SUMMARY

Testosterone in women:

 

[madman]

Sex-chromosomes influence CVD risk. independent of sex hormones

Menopause MAPS ONTO each woman's pre-existing risk

 

[madman]

Conclusions

 

[madman]

Thread 'Testosterone levels decline with age, not menopause, despite what you’ve heard'

Oct 25, 2025

Researchers proposed the idea of an “testosterone deficiency syndrome” in menopausal women more than 20 years ago. This was before testosterone had been measured across women’s lifespans and before robust studies of the relationships between blood testosterone levels and specific symptoms.

Our research refutes the belief that menopause causes testosterone deficiency, and that testosterone supplementation is an essential part of MHT.

Testosterone levels decline with age, not menopause, despite what you’ve heard

Testosterone is widely promoted as an essential part of menopausal hormone therapy to treat low mood, brain fog and low energy. But new research challenges this.

theconversation.com

Social media...

• madman
• menopause; testosterone; estrogen; hrt
• Replies: 6
• Forum: HRT in Women

 

[madman]

Thread 'The WHI: A Focus on Hormone Therapy (aka Lies, Damn Lies, and Statistics)'

Jun 11, 2022

To launch the Newson Health Menopause Society, Professor James Simon delivers an in-depth analysis of the 2002 WHI study.

• madman
• hrt; whi; estradiol; pre-post menopause
• Replies: 31
• Forum: HRT in Women

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