Bloodwork after 4 months, estradiol concern?

40 year old male, started in December on 175 mg testosterone enanthate and 500iu HCG a week, divided in two pins.

Generally I feel good, I could have more energy though, sometimes I feel tired. Mood is good, slightly faster annoyed but it's subtle. Libido is great, motivation high.

Ok, now for the results (my cholesterol was already slightly elevated before starting TRT):

Edit: check the pdf for the correct values
 

Attachments

Last edited:
Estradiol: 216.9 pmol/L → 59 pg/mL
- Testosterone: 39.6 nmol/L → 1143 ng/dL
- Free Testosterone: 0.961 nmol/L → 27.7 pg/mL
Men convert .02-.03% of T to E2, so high estrogen alongside high T is to be expected.

- Hematocrit: 0.41 L/L → 41%
- MCV: 82 fL → 82 µm^3
- MCH: 1.59 fmol → 26 pg
- MCHC: 1.86 mmol/L → 186 g/L
You're likely iron deficient/anemic. Check ferritin and iron saturation.
 
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So according to these values, and the reference values (3rd row), I'm on the high side of all those, high means low iron/ferritin?
 

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Estradiol: 216.9 pmol/L → 59 pg/mL
- Testosterone: 39.6 nmol/L → 1143 ng/dL
- Free Testosterone: 0.961 nmol/L → 27.7 pg/mL
Hemoglobin: 8.5 mmol/L → 13.8 g/dL
- Hematocrit: 0.41 L/L → 41%
- MCV: 82 fL → 82 µm^3
- MCH: 1.59 fmol → 26 pg
- MCHC: 1.86 mmol/L → 186 g/L

So according to these values, and the reference values (3rd row), I'm on the high side of all those, high means low iron/ferritin?
I thought the values with the arrows were the results. I'm unable to open the attached file.

In that case, your symptoms are likely from too many androgens.
 
Screenshots of the PDF included here
 

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hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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