Bioenergetics - Low TSH, low estradiol and high testosterone as indicative of suppressed thyroid function with high "tissue-bound" estrogen.

[Jim Marlowe]

Here's a post on X.com by Danny Roddy discussing the bioenergetic interpretation of high cholesterol, low TSH, low blood estrogen with high testosterone, and high SHBG.

https://twitter.com/x/status/1877415385747669340

 

[Vince]

I would have a complete thyroid panel not just TSH. The thyroid function may be normal.

 

[Jim Marlowe]

I would have a complete thyroid panel not just TSH. The thyroid function may be normal.

Sure, that's what conventional wisdom would say. What Danny is saying is that the combination is indicative of hypothyroidism. From Roddy:
"Prolonged cortisol excess and adrenaline can lower TSH" — Ray Peat

"Aging, infection, trauma, prolonged cortisol excess, somatostatin, dopamine or L-dopa, adrenaline (sometimes; Mannisto, et al., 1979), amphetamine, caffeine and fever can lower TSH, apart from the effect of feedback by the thyroid hormones, creating a situation in which TSH can appear normal or low, at the same time that there is a real hypothyroidism." -Ray Peat PhD

Stratakis, C.A., and Chrousos, G.P. Neuroendocrinology and pathophysiology of the stress system. Ann N Y Acad Sci. 1995 Dec 29;771:1-18. "During stress, there is suppressed secretion of TSH..." https://pubmed.ncbi.nlm.nih.gov/8597390/

 

[Seagal]

Here's a post on X.com by Danny Roddy discussing the bioenergetic interpretation of high cholesterol, low TSH, low blood estrogen with high testosterone, and high SHBG.

https://twitter.com/x/status/1877415385747669340

Interesting. What is his bioenergtic interpretation of testosterone deficiency?

 

[Vince]

Sure, that's what conventional wisdom would say. What Danny is saying is that the combination is indicative of hypothyroidism. From Roddy:
"Prolonged cortisol excess and adrenaline can lower TSH" — Ray Peat

"Aging, infection, trauma, prolonged cortisol excess, somatostatin, dopamine or L-dopa, adrenaline (sometimes; Mannisto, et al., 1979), amphetamine, caffeine and fever can lower TSH, apart from the effect of feedback by the thyroid hormones, creating a situation in which TSH can appear normal or low, at the same time that there is a real hypothyroidism." -Ray Peat PhD

Stratakis, C.A., and Chrousos, G.P. Neuroendocrinology and pathophysiology of the stress system. Ann N Y Acad Sci. 1995 Dec 29;771:1-18. "During stress, there is suppressed secretion of TSH..." https://pubmed.ncbi.nlm.nih.gov/8597390/

It could also mean your thyroid is working perfectly

 

[Jim Marlowe]

Interesting. What is his bioenergtic interpretation of testosterone deficiency?

It broad terms, it is suboptimal energy production from various causes including in large part consumption of PUFA. Burning glucose primarily (not entirely) through oxidative phosphorylation is the most efficient method (i.e. produces the most electrons for ATP). Bioenergetics rejects the rate limit theory of living that people like Brian Johnson ascribe to (slowing resting heart rate and lowering body temperature under the mistaken assumption that one does not want to "wear out" the body faster), which has been largely rejected in the research. Bioenergetics posits that higher metabolism and higher resting heart rate (keeping in mind that highly trained people will always have lower heart rate due to efficiency) are preferred for health and longevity.

High cholesterol and low T is indicative of impaired metabolism, including low thyroid function. Cholesterol is not being converted to the needed hormones.
Diabetics, for example, rely primarily on fat metabolism--fatty acid oxidation.
One other thing about Ray Peat, he apparently understood the importance of DHT, which is interesting given the recent attention in the lengthy thread on here. The bioenergetics people are definitely on board with increasing DHT. All of this is me paraphrasing the concepts.

 

[Jim Marlowe]

It broad terms, it is suboptimal energy production from various causes including in large part consumption of PUFA. Burning glucose primarily (not entirely) through oxidative phosphorylation is the most efficient method (i.e. produces the most electrons for ATP). Bioenergetics rejects the rate limit theory of living that people like Brian Johnson ascribe to (slowing resting heart rate and lowering body temperature under the mistaken assumption that one does not want to "wear out" the body faster), which has been largely rejected in the research. Bioenergetics posits that higher metabolism and higher resting heart rate (keeping in mind that highly trained people will always have lower heart rate due to efficiency) are preferred for health and longevity.

High cholesterol and low T is indicative of impaired metabolism, including low thyroid function. Cholesterol is not being converted to the needed hormones.
Diabetics, for example, rely primarily on fat metabolism--fatty acid oxidation.
One other thing about Ray Peat, he apparently understood the importance of DHT, which is interesting given the recent attention in the lengthy thread on here. The bioenergetics people are definitely on board with increasing DHT. All of this is me paraphrasing the concepts.

https://twitter.com/x/status/1875604453652345076

 

[Vince]

It broad terms, it is suboptimal energy production from various causes including in large part consumption of PUFA. Burning glucose primarily (not entirely) through oxidative phosphorylation is the most efficient method (i.e. produces the most electrons for ATP). Bioenergetics rejects the rate limit theory of living that people like Brian Johnson ascribe to (slowing resting heart rate and lowering body temperature under the mistaken assumption that one does not want to "wear out" the body faster), which has been largely rejected in the research. Bioenergetics posits that higher metabolism and higher resting heart rate (keeping in mind that highly trained people will always have lower heart rate due to efficiency) are preferred for health and longevity.

High cholesterol and low T is indicative of impaired metabolism, including low thyroid function. Cholesterol is not being converted to the needed hormones.
Diabetics, for example, rely primarily on fat metabolism--fatty acid oxidation.
One other thing about Ray Peat, he apparently understood the importance of DHT, which is interesting given the recent attention in the lengthy thread on here. The bioenergetics people are definitely on board with increasing DHT. All of this is me paraphrasing the concepts.

That's one of of the reasons I supplement with creatine is to increase my DHT. My resting heart rate is in the '60s. I wish it was lower. Onel of my stepsons heart rate is in the low 50s. He is a workout freak. I try not to spike my insulin. I eat low-carb.

 

[Jim Marlowe]

That's one of of the reasons I supplement with creatine is to increase my DHT. My resting heart rate is in the '60s. I wish it was lower. Onel of my stepsons heart rate is in the low 50s. He is a workout freak. I try not to spike my insulin. I eat low-carb.

You wish it was lower as a result of cardiac fitness or lower because you subscribe to the rate-of-living theory?

 

[Vince]

You wish it was lower as a result of cardiac fitness or lower because you subscribe to the rate-of-living theory?

Fitness, the better shape we are in should also benefit our hearts. It would be cool to be in so good shape that my heart resting rate will be in the low 50s.

 

[Jim Marlowe]

Ray Peat on why "normal" thyroid function is misleading based the arbitrary determination that only five percent of the population was hypothyroid.

https://twitter.com/x/status/1878192812375568547