Berberine and HRT

I've used Berberine with great success. Doc wanted to put me on Metformin, but asked that we give Berberine a try first since Metformin is known to cause some digestive distress in some people.

My A1c was creeping up on the 5.8 to 6.0 range and I couldn't get it to come down no matter what I did (altered diet, etc.). Berberine and Metformin dose 1:1 the same.

Voila! A few weeks later, A1c was down to a comfortable 4.2.

So now keep an occasional eye on fasting glucose levels. When I see that creep up above 100 in the morning upon waking, I know it's time to get back on the Berberine.
 
I also am experiencing success with Berberine.
After 5 weeks of 500mg/daily I had blood work and my A1C went down 0.3
I do time restricted eating and my diet consist of 95% meat/eggs.
At 58 y/o, 5"9' and 170 lbs nothing else I tried lowered my A1C until Berberine.
Looking forward to next blood panel in a few months.
 
 
I haven't had a good start with it yet.
I started at 500 mg a day but discontinued it as I have just found out that I have shingles.
Antiviral meds for now.....
 

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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

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Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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