Arimidex ONCE A WEEK ???

I understand the trial and error aspect of Arimidex dosages and how the dosage amount depends on the individual.

What I don't understand is why it is possible to have a dosage frequency that is so much greater than Arimidex's half-life of 46.8 hours.

For example, with testosterone cypionate we are warned against doing injections only once per 2 weeks because testosterone levels will fluctuate too much and crash if we wait 2 weeks before taking the next injection.

It seems intuitive that estrogen and Arimidex would be similar. If we take Arimidex once every 3.5 days when the half-life is about 2 days then our estrogen levels would fluctuate too much and increase significantly when we wait more than 2 or 3 days to take the next dosage.

I'm sure there is a reason why it is appropriate for the dosage frequency of Arimidex to be much longer than the half-life (unlike testosterone) but I would like to know what that reason is so I can better understand dosage frequencies for both testosterone and Arimidex.
 

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This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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