Anyone used topical estrogen?

I'm very sensitive to high estradiol (anything >35), especially the classic negative effects on well being. However, in the rare instances that my estradiol is low, I've definitely used topical estradiol cream. It fixes my low estradiol symptoms, also related to well being, in very short order.

Regarding libido, I'm not sure my estradiol levels really affect that. My desire for sex is pretty much constant no matter what. However, my ability to get and maintain an erection, and quality of orgasm is greatly impacted when estradiol is either high or low.
 
Anybody used topical estradiol? What were effects? Interested in sense of well being and libido that may have been effected
I did. I used it because I was dropping my testosterone dose and I started getting achy joints. The topical E did reduce my achy joints. I did not notice any difference in well being or libido.
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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