Anyone ever had T3 raise their E2 and free T and cause erectile dysfunction?

Anonymon

Active Member
Been on HRT for a few years and still ironing out some lingering issues. Historically I can get my total T to 1300ish with a 200-215 free T and 50-57 E2 without an AI or anything with daily small injections of testosterone and HCG. My free T3 on labs is usually a little low (3.0-3.2), my rT3’s usually running high (24-25), and I have many distinct hallmark hypothyroid symptoms, however.

Trying T3 in either sustained release or any form really, I feel good at first, then my free T quickly skyrockets to the low 300s and my E2 to 90, which among other things breaks my ability to maintain an erection and makes that whole area somewhat numb. AIs do nothing for it. I also don’t feel like someone with that much free testosterone. In general throughout all this and before I have a marked inability to retain muscle glycogen or burn body fat, among other things.

Anyone ever dealt with something like that? Ceasing the T3 seemingly stops it, though this past time when I did, the symptoms are lingering on, and I’m unable to deal with the hypothyroid situation.
 

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This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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