Anastrazole and other ai’s may activate the estrogen receptor in place of estradiol

[JA Battle]

Anastrozole has an Association between Degree of Estrogen Suppression and Outcomes in Early Breast Cancer and is a Ligand for Estrogen Receptor α - PubMed

This matched case-control clinical study revealed that levels of estrone and estradiol above identified thresholds after 6 months of adjuvant anastrozole treatment were associated with increased risk of an EBCE. Preclinical laboratory studies revealed that anastrozole, but not exemestane or...

pubmed.ncbi.nlm.nih.gov

 

[Wolverine]

Interesting read. Does this mean that anastrozole is better or worse than exemestane/letrozole for men on TRT? I've tried both anastrozole and exemestane. Anastrozole was stronger and brought my E down more.

 

[JA Battle]

the “zoles” would both fit this ticket potentially, but possibly letrozole to less of a degree.

anastrazole exerts it’s effects similarly to DHt as it actually converts into a rather potent androgen.

I’m not sure which is better or worse. I have never taken an ai. I tend to have rather low estradiol numbers. I periodically experiment with supplementing estradiol.