Allopregnanolone (Caproate)

t_spacemonkey

Well-Known Member
I am not in any way affiliated or selling stuff, but tried an order with allop. caproate from 5arsociety, which I consider a legitimate 'chemist'.
allop. is an FDA approved treatment for postpartum depression, with a synthetic costing something like 15k/14 days called Zuranolone which is also a treatment for depression, PTSD and other things.
tried a 7mg injection yesterday, and got a strong gaba-ergic effect. a bit like a holistic benzo (which i will never take again), but less chemical. after heavy sedation which lasted 1h it transitioned to a general feeling of wellbeing. sleep felt very deep and refreshing, which I attribute to gaba modulation. I do have concern about gaba-rebound, but apparently this is a very low risk with sporadic use.
Overall it is a very potent substance with extreme potential. I highly suspect it won't be available through general channels, since it has FDA analogs on the market and there is no money to be made by pharma here.
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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