DEEP DIVE:
Strategies to Increase Allopregnanolone
A Comprehensive Review for Mental Health Support
1. What is Allopregnanolone?
Allopregnanolone (ALLO) is a neurosteroid synthesized from progesterone that acts as a potent positive allosteric modulator of GABA-A receptors. [1,2] Its potency at...
I am not in any way affiliated or selling stuff, but tried an order with allop. caproate from 5arsociety, which I consider a legitimate 'chemist'.
allop. is an FDA approved treatment for postpartum depression, with a synthetic costing something like 15k/14 days called Zuranolone which is also a...
Allopregnanolone: Regenerative therapeutic to restore neurological health (2023)
Gerson D. Hernandez, Roberta D. Brinton
ABSTRACT
Chronic stress has been proposed as a driver of altered brain structure and function, including the pathogenesis of neurodegenerative diseases, and a driver of...
Progestogen-mediated neuroprotection in central nervous system disorders (2022)
Bassani TB, Bartolomeo CS, Oliveira RB, Ureshino RP
Abstract
Neuroactive steroids can be synthetic or endogenous molecules produced by neuronal and glial cells and peripheral glands. Examples include estrogens...
I’ve read a few interesting things on low dose ssri boosting allopregnenolone. And not acting as an ssri at all. I’m the past I actually did better on trt with low dose lexapro. Now I’m going to give low dose Prozac a shot. Here is an article that put me on to it...
Development and validation of an LC-MS/MS assay for the quantification of allopregnanolone and its progesterone-derived isomers, precursors, and cortisol/cortisone in pregnancy
Abstract
Neuroactive steroids are potent neuromodulators that play a critical role in both maternal and fetal health...
In this video dr Mark Gordon, starting at 9min, explains how using good level of TRT can "burn" 5 alpha reductase enzyme, that beside being responsible for converting Test into DHT, it is also responsible for converting Progesterone into Allopregnanolone in the brain.
Throughout the years on...
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