Gene
I like my Patron, but I take it with the knowledge that I monitor my estradiol/testosterone and supplement my testosterone
http://www.nejm.org/doi/pdf/10.1056/NEJM197610072951501
Effect of Alcohol (Ethanol) Administration on Sex-Hormone Metabolism in Normal Men
Abstract
To determine whether ethanol per se affects testosterone metabolism, alcohol was administered to normal male volunteers for periods up to four weeks, resulting in an initial dampening of the episodic bursts of testosterone secretion followed by decreases in both the mean plasma concentration and the production rate of testosterone. The volunteers received adequate nutrition and none lost weight during the study, which tended to exclude a nutritional disturbance as the cause of the decreased testosterone levels. The changes in plasma luteinizing hormone suggested both a central (hypothalamus-pituitary) and gonadal effect of alcohol. In addition, alcohol consumption increased the metabolic clearance rate of testosterone in most subjects studied, probably owing to the combined effects of a decreased plasma binding capacity for the androgen and increased hepatic testosterone A-ring reductase activity. These results indicate that alcohol markedly affects testosterone metabolism independently of cirrhosis or nutritional factors. (N Engl J Med 295:793–797, 1976)
http://pubs.niaaa.nih.gov/publications/aa26.htm
Alcohol and Hormones
Alcohol is directly toxic to the testes, causing reduced testosterone levels in men. In a study of normal healthy men who received alcohol for 4 weeks, testosterone levels declined after only 5 days and continued to fall throughout the study period (17). Prolonged testosterone deficiency may contribute to a "femininization" of male sexual characteristics, for example breast enlargement (18).
In addition, animal studies have shown that acute alcohol administration affects the release of hormones from the hypothalamus and pituitary (5). Even without a detectable reduction of testosterone levels, changes in these hormones can contribute to the impairment of male sexual and reproductive functions (19). Alcohol also may interfere with normal sperm structure and movement by inhibiting the metabolism of vitamin A (20), which is essential for sperm development.