Adding Anastrozole, how much should I lower dose?

[watson350]

if your at 650mg per week on 120mg test cyp with 500 iu HCG. What would .125mg of Anastrozole put you at, anecdotal experience is welcome and appreciated.

 

[Cataceous]

In this situation an aromatase inhibitor should not affect your free testosterone. It could indirectly affect total testosterone by reducing estradiol. Lower estradiol can lead to lower SHBG and therefore lower total testosterone as well. Your dose of testosterone has likely suppressed LH and FSH to low levels, and a small dose of anastrozole will not change this.

 

[watson350]

In this situation an aromatase inhibitor should not affect your free testosterone. It could indirectly affect total testosterone by reducing estradiol. Lower estradiol can lead to lower SHBG and therefore lower total testosterone as well. Your dose of testosterone has likely suppressed LH and FSH to low levels, and a small dose of anastrozole will not change this.

And what about DHT? the conversion has to go somewhere else no?

 

[Systemlord]

And what about DHT? the conversion has to go somewhere else no?

Excessively elevated DHT will have an anti-estrogen effect and lower your estrogen. There’s no way to predict where the AI will put your estrogen because we don’t know how sensitive you are to AI’s. That would be like trying to predict your tolerance to alcohol and how many beers would it take to get you wasted.

Any amount of AI will crash my estrogen, even a 1/10th of 0.050.

 

[watson350]

Excessively elevated DHT will have an anti-estrogen effect and lower your estrogen. There’s no way to predict where the AI will put your estrogen because we don’t know how sensitive you are to AI’s. That would be like trying to predict your tolerance to alcohol and how many beers would it take to get you wasted.

Any amount of AI will crash my estrogen, even a 1/10th of 0.050.

Ill get blood work soon, so its unreasonable for me consider anastrozole COULD raise my total T to 850 from 650 with just .125mg of anastrozole a week

 

[Cataceous]

And what about DHT? the conversion has to go somewhere else no?

DHT is created from free testosterone. The rate of creation is not expected to change with lower estradiol. This means free DHT should not change. But as with testosterone, if SHBG is driven down by the lower estradiol then total DHT may drop.

I should add that I'm ignoring the tiny amount of extra free testosterone you'll get from reduced aromatization. That's because even if you knock out all aromatization it's only around 0.2-0.6% of testosterone.

I'll further add that the situation is quite different for men not on TRT with functioning HPTAs. Then the reduction in estradiol can be a strong stimulus for additional production of testosterone.

 

[watson350]

DHT is created from free testosterone. The rate of creation is not expected to change with lower estradiol. This means free DHT should not change. But as with testosterone, if SHBG is driven down by the lower estradiol then total DHT may drop.

I should add that I'm ignoring the tiny amount of extra free testosterone you'll get from reduced aromatization. That's because even if you knock out all aromatization it's only around 0.2-0.6% of testosterone.

I'll further add that the situation is quite different for men not on TRT with functioning HPTAs. Then the reduction in estradiol can be a strong stimulus for additional production of testosterone.

The HCG stimulation of the leydig cells would suggest the endogenous turnover to testoserone/T in the presence of a AI is none trivial. SHBG goes down increasing free T and free dht .Nevertheless, thank you for your input

 

[Cataceous]

The HCG stimulation of the leydig cells would suggest the endogenous turnover to testoserone/T in the presence of a AI is none trivial. SHBG goes down increasing free T and free dht .Nevertheless, thank you for your input

Regardless of whether the testosterone is endogenous or exogenous, the fraction that is aromatized is trivial, and you'd be unable to detect such an increase, subjectively, or even with current lab tests. On the other hand, knocking down a big fraction of estradiol is what can cause significant subjective and quantifiable effects.

The SHBG level does not affect free testosterone. The belief that it does is just a myth that won't die. See the details in this post.

 

[WhiteMale]

if your at 650mg per week on 120mg test cyp with 500 iu HCG. What would .125mg of Anastrozole put you at, anecdotal experience is welcome and appreciated.

What? Clarify this 650mg per week on 120mg test cyp,
This is all so personal you can't quantify it in the way you're trying to do it. Too it would be ill advised to talk it through with out some T/FT/E2 labs and what you think your Elevated/High Estrogen symptoms are that that they need reduced.