A Novel Combination Therapy for Testosterone Deficiency: Clomiphene Citrate With Oral TU Provides Symptomatic Relief With HPGA Preservation

madman · Dec 4, 2025

https://academic.oup.com/jsm/article/22/Supplement_4/qdaf320.053/8375197

A Novel Combination Therapy for Testosterone Deficiency: Clomiphene Citrate With Oral Testosterone Undecanoate Provides Symptomatic Relief With Hypothalamic-Pituitary-Gonadal Axis Preservation

A video from Andrew Sun, posted on Dec 3, 2025.

www.vumedi.com

madman · Dec 4, 2025

Background and Methods

madman · Dec 4, 2025

Results

madman · Dec 4, 2025

* Larger prospective trials warranted

Discussion

madman · Dec 4, 2025

Thread 'New Breakthrough for Low T: Combining Clomiphene Citrate with Oral TU (Kyzatrex) Boosts T Levels, Preserves Fertility, and Improves Symptoms'

Aug 20, 2025

Nelson's house always on point here!

You know where it's at LOL!

* The mean baseline total testosterone was 264 ± 61 ng/dL. After three months of CC monotherapy, mean total testosterone significantly increased to 522 ± 101 ng/dL; FSH and LH levels also rose significantly. However, patients reported minimal symptomatic improvement. Upon adding oral TU to the CC regimen for an additional three months, mean peak total testosterone levels significantly increased to 1052 ± 293 ng/dL. Notably, with combination therapy, FSH levels (mean 5.2 ± 3.7 mIU/mL) and LH...

madman · Dec 4, 2025

Thread 'KYZATREX® Safe for your liver: Lymphatic Absorption'

Oct 12, 2025

* The good news is that KYZATREX was specifically designed to be absorbed lymphatically. This means it bypasses your liver avoiding the liver toxicity associated with oral testosterone medications of the past.

Kyzatrex® (testosterone undecanoate) an oral testosterone therapy

Taken twice daily with food ideally a meal with some healthy fats

Foods with healthy fats help the body absorb the medicine, after swallowing the Kyzatrex® capsule dissolves in the digestive system and releases its...