6 mo. into TRT and level dropped with increase in freqency of injections. Stumped.

In this scenario, Instead of the 100mg. every 6 days. Would and increase of 100mg. twice weekly show an increase in my SHGB? Then would the increase in SHGB allow my testosterone levels to increase as well? Thanks.

SHBG seeks its own level. It's a rule of the road: low SHBG, smaller frequent injections. At least twice a week, possibly every other day, or - as I found - daily injections (16mg every day brought my levels to just at 1000).

Your proposal of 100mg twice weekly is another recipe for disaster for most men. High estradiol being just one likely problem...
 
SHBG seeks its own level. It's a rule of the road: low SHBG, smaller frequent injections. At least twice a week, possibly every other day, or - as I found - daily injections (16mg every day brought my levels to just at 1000).

Your proposal of 100mg twice weekly is another recipe for disaster for most men. High estradiol being just one likely problem...

At 16mg every day, How long did it take your level to get to 1000? That's only 112mg. a week. That doesn't necessary work for everyone, right?
 
At 16mg every day, How long did it take your level to get to 1000? That's only 112mg. a week. That doesn't necessary work for everyone, right?
Everyone is certainly different. My levels reached stability at that level within a month. You seem very committed to large doses of testosterone...which may or may not be in your best interest.
 
Guys with low SHBG (generally) clear T very quickly from their system - that means that if they inject once a week or even twice a week, their T level may drop so fast between doses that they still don't feel good and their levels are bouncing from low to high(er) all of the time. I am a low SHBG guy and I am one of many here that injects a small amount of T daily with an insulin syringe to maintain a stable T level.

Hi ERO,

What dose and frequency do you inject and are you happy with your levels?
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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