2x day cream - surprising stability

S1W

Well-Known Member
After all the talk about scrotal cream, I just had to try it for myself. I had used cream before, but not exclusively on the scrotum and only once per day.

This time around, I tried 100mg AM and 50mg PM, applied all to scrotum. I took one set of labs before my morning application, about 12 hours after my 50mg evening application, and got:

TT: 893 (264-916) FT: 29.7 (6.8-21.5)

I then applied my morning 100mg of cream, and went back to the lab about 5 hours later for a peak reading:

TT: 896 (264-916) FT: 29.5 (6.8-21.5)

So...basically no difference between peak/trough, which surprised me. Of course lab error is always a possibility. My SHBG on cream seems to hover around 27.

E2 is the only other lab I tested due to costs, and it came in at 37 (8-35).

Note that I'm not claiming that this "stability" is a good or a bad thing, it was just....interesting. Especially since we often hear guys say things like using cream creates a more "natural" swing. If you're using it 2x a day, it doesn't.
 
Last edited:
After all the talk about scrotal cream, I just had to try it for myself. I had used cream before, but not exclusively on the scrotum and only once per day.

This time around, I tried 100mg AM and 50mg PM, applied all to scrotum. I took one set of labs before my morning application, about 12 hours after my 50mg evening application, and got:

TT: 893 (264-916) FT: 29.7 (6.8-21.5)

I then applied my morning 100mg of cream, and went back to the lab about 5 hours later for a peak reading:

TT: 896 (264-916) FT: 29.5 (6.8-21.5)

So...basically no difference between peak/trough, which surprised me. Of course lab error is always a possibility. My SHBG on cream seems to hover around 27.

E2 is the only other lab I tested due to costs, and it came in at 37 (8-35).

Note that I'm not claiming that this "stability" is a good or a bad thing, it was just....interesting. Especially since we often hear guys say things like using cream creates a more "natural" swing. If you're using it 2x a day, it doesn't.


Peak for creams is 1-2 hours after dosing, so you are definitely higher than your labs. Hey...if it's working...roll with it.
 
After all the talk about scrotal cream, I just had to try it for myself. I had used cream before, but not exclusively on the scrotum and only once per day.

This time around, I tried 100mg AM and 50mg PM, applied all to scrotum. I took one set of labs before my morning application, about 12 hours after my 50mg evening application, and got:

TT: 893 (264-916) FT: 29.7 (6.8-21.5)

I then applied my morning 100mg of cream, and went back to the lab about 5 hours later for a peak reading:

TT: 896 (264-916) FT: 29.5 (6.8-21.5)

So...basically no difference between peak/trough, which surprised me. Of course lab error is always a possibility. My SHBG on cream seems to hover around 27.

E2 is the only other lab I tested due to costs, and it came in at 37 (8-35).

Note that I'm not claiming that this "stability" is a good or a bad thing, it was just....interesting. Especially since we often hear guys say things like using cream creates a more "natural" swing. If you're using it 2x a day, it doesn't.
Do you have solid Libido on your cream protocol? Do you use hCG or anything else in your protocol?
 
Do you have solid Libido on your cream protocol? Do you use hCG or anything else in your protocol?

Yes I do. However, libido was never an issue for me even before TRT. If anything though, TRT and cream in particular increases it.
 

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Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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