10 Years on TRT and Only Recent Libido Issues

[SS1LE]

This is a great multi, has about a 100% of daily values on most things vs 1000%

https://www.amazon.com/NATURELO-One-Daily-Multivitamin-Men/dp/B01MA5K82Q?ref_=ast_sto_dp&th=1

 

[SS1LE]

There are many micronutrients in multivitamins that each make me feel like garbage in the high doses they typically use. I often wonder if other people are similarly affected and are not self-aware enough to notice the adverse effects. I've tested all of the nutrients independently and the offenders include:

• Higher than RDA thiamine
• Higher than RDA riboflavin
• Any amount of niacin/niacinamide
• 400 mcg+ methylfolate
• More than 10-20 mg B6
• Any amount of zinc
• Any amount of chromium
• Higher than RDA vitamin E
• Higher than RDA vitamin C
• 5000+ iu retinol
• 2000+ iu Vitamin D

Some of the adverse effects include fatigue, depressed mood, spaciness / brain fog, insomnia, and reduced libido.

I would absolutely include a multivitamin in your list of suspicions if anything is feeling off.

I agree here as well, sometimes certain nutrients make me feel awful as well. That would be Vit D 2000iu+, magnesium usually 200mg+ (Elemental), And super high doses of B12

 

[Forty2]

This is a great multi, has about a 100% of daily values on most things vs 1000%

https://www.amazon.com/NATURELO-One-Daily-Multivitamin-Men/dp/B01MA5K82Q?ref_=ast_sto_dp&th=1

Why is the calcium and magnesium content so low?
Doesn't the daily value of nutrients need to be above 100% of the RDA since not all of the supplement is absorbed?

 

[FunkOdyssey]

I agree here as well, sometimes certain nutrients make me feel awful as well. That would be Vit D 2000iu+, magnesium usually 200mg+ (Elemental), And super high doses of B12

I forgot to mention magnesium. A decent sized dose of magnesium will leave me feeling sedated and apathetic for the entire day (or next day if taken at night).

Feel much better getting this from food. Magnesium tests have been in the top half of normal range on carnivore diet.

 

[wes6363]

What is MV?

Do you consume stevia?

Do you have anything to track sleep quality and SpO2 (to identify apnea) like an oura ring? How does that look?

You said, "No other meds that cause libido side effects." Are you taking any other medications besides TRT?

Multivitamin- One a Day Men’s. Negative on Stevia. I don’t have anything that detailed for sleep; I was tested for sleep apnea around 5yrs ago and it was fine though. Usually get 8.5-9hrs a night.
Other meds- metoprolol 25mg and Olmasartan 5mg a day that I’ve been on forever for blood pressure, that’s under control. Psych put me on Wellbutrin 450 some weeks back to see if that helped for libido but no effect.
Also, I tried taking a Cialis 9mg over the weekend to try anything at this point and zero effect. It usually had effects in the past.
I’ll cut out the MV next. I stopped taking L-Dopa & calcium.

 

[FunkOdyssey]

Multivitamin- One a Day Men’s

This one isn't too bad in terms of the dosages but I'd still experiment with dropping it for a bit.

Other meds- metoprolol 25mg

 

[Systemlord]

Throw iron deficiency in there too. I confirmed iron deficiency from using Bisoprolol, a beta-blocker. My ferritin was seen reducing 14 points every ten days. The beta-blocker without a doubt caused stomach cramping which I believe caused malabsorption.

After I stopped the beta-blocker 4 months later my ferritin was above the normal ranges where before stopping I was on 6 iron supplements per day and ferritin was towards the top end of normal.

While there's no direct, well-established interaction between metoprolol and iron deficiency, some studies suggest a potential link. Specifically, some research indicates that beta-blockers like metoprolol might be associated with a slightly increased risk of developing new-onset anemia, which can include iron deficiency. However, the link is not definitive and further research is needed.

Here's a more detailed look at the issue:
Potential Link Between Metoprolol and Anemia/Iron Deficiency:

• Beta-blockers and Anemia:
  Some studies, particularly those looking at patients with heart failure, have suggested a correlation between beta-blocker use and the development of new-onset anemia.
  
  
• • Metoprolol's Role:
    Metoprolol, being a beta-blocker, falls into the category of medications potentially associated with anemia.
  • Mechanisms:
    The exact mechanisms by which beta-blockers might contribute to anemia are not fully understood, but some potential factors include:
    • • Impact on erythropoiesis: Erythropoiesis, the process of red blood cell production, might be affected by the use of beta-blockers.
      • Changes in iron absorption or metabolism: While not directly shown, some researchers hypothesize that beta-blockers might indirectly influence iron absorption or utilization.
  • Studies:
    A study in the COMET trial (Carvedilol or Metoprolol European Trial) showed that patients on metoprolol had a slightly increased risk of developing new-onset anemia, but this was not statistically significant. Other studies have also investigated the relationship between beta-blockers and anemia in various populations.

 

[wes6363]

This one isn't too bad in terms of the dosages but I'd still experiment with dropping it for a bit.



View attachment 51772

Yeah I know that it can cause issues, especially in high doses. I’ve been on that for around 7yrs though. I also experimented not taking it a couple of months ago and no change, except for my BP.
And I can still perform fine, even wake up in the morning fine. Just no drive at all.

 

[SS1LE]

Why is the calcium and magnesium content so low?
Doesn't the daily value of nutrients need to be above 100% of the RDA since not all of the supplement is absorbed?

You get a lot of calcium and magnesium through food if you eat healthy, I don't think one large dump of any nutrient is good. This multi gets you some of the basics without going overboard.

 

[Belekas]

I forgot to mention magnesium. A decent sized dose of magnesium will leave me feeling sedated and apathetic for the entire day (or next day if taken at night).

Feel much better getting this from food. Magnesium tests have been in the top half of normal range on carnivore diet.

Same with me. Seems I can't get any form of Mag to work for me. Gave girl Mag Bisglycinate and she got depressed and not feeling well too. So we just try to get it from food as well. Haven't tried liquid Mag Chloride though so as last resort might give it a try one day.

 

[ed031561]

Stop the DIM and see if it improves.

 

[excelnelg]

When you find what helps you I hope you share it with the rest of us who are in the same boat.

 

[wes6363]

Stopped taking the DIM, MV, calcium L-Dopa, etc. No changes as of yet. I met with psych again to reanalyze anything going on and they said they don’t believe it’s anything mental. They’re focused on the HGH and said to see the endo. I’ll report back when I make some headway.