estradiol

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  1. C

    Managing E2 without the use of AI: Suggestions?

    I am on the following: -40 mg test-c 2x weekly -500 iu HCG 2x weekly I recently discontinued my ai as it makes me feel very bad even at just .125 mg and brings my e2 to low 20s. I have a high SHBG, historically around 55-65 (15-55) and my Total T runs around 1100 with free T anywhere between...
  2. Reason

    Fatigue, anger, swollen ankles, etc.

    I'm currently dealing with a few things that may or may not be TRT related. I scoured these forums to see if I could find help with no conclusive answers. Background: 38, 5'11", 205lbs TRT since Feb 2018, currently 138mg/week (3x) + 500IU HCG (2x) + .125mg Anastrozole 2-3x as needed DHEA 25mg...
  3. T

    Anastrozole - Stabilization

    I have been struggling with estrogen problems for over a year. I just can’t seem to get dialed in. I was at .1 anastrozole every 3 days, and after 19 days I went high, so I adjusted to .1 every other day. That brought me down to normal after a few days, then a little low, and now high after 15...
  4. E

    High E2 Symptoms?

    So as I posted in another thread, my E2 came back high (65) after my first 8 weeks at 160mg/week. Didn’t have much symptoms but defy and I agreed to lower me to 140mg/week and 0.1mg to 0.2mg Anastrozole weekly. I know it’ll take time for my dose change to reduce E2 symptoms but a few new things...
  5. S

    OPEN STUDY: What levels of free T, Testosterone, E2, prolactin, cortisol do you feel best at?

    All of us are following our protocols quite blindly, trying to optimise but unsure what values to optimise to. The lab ranges vary between countries and labs. The NHS for example sets it upper T limit at 750 - whereas many people in the US naturally have higher levels than this and are perfectly...
  6. A

    How much does Estradiol generally vary between injections?

    If one was on a standard protocol of twice weekly injections, with a normal mid-range SHBG levels, how much could you expect Estradiol to vary between peak and trough levels? For example if someone had an E2 sensitive reading of something like 20 at their trough. Thanks.
  7. W

    Clomid and AI (w/ low T & low E2)

    Summary of my lab work: Okay total T Low Free T High SHBG Low LH Underperforming Thyroid Low E2 Estradiol senstive - 7.4 (normal = 8.0 - 35.0) Doctor has started me on 12.5 Clomid (EOD) and AI (Anastrozole) (3x per week) From what I gather, the treatment plan lis designed to elevate my free T...
  8. Z

    High Prolactin and Estradiol in 33 y/o

    Been a while since I was on this site, but I just discovered this dedicated Prolactin subforum, looks like theres loads of good stuff stickied, so have lots of reading to do! In the mean time I thought I'd post here. I started a thread in the TRT subforum a while back, and have since had a few...
  9. D

    Ditch your AI now - you don't need it!

    I'm a long time lurker and haven't posted much (perhaps even never) but I felt I should contribute something in return: I have very mild gyno that I've had most of my life. As soon as my E2 goes up it starts getting sore. That's when I USED to take an arimidex and it would go away. This time...
  10. J

    Exogenous Estrogen

    39yrs old, 260lbs Iinitial labs had estradiol at 127.4 pg/ml) Began aromasin at 12.5mg 3x wk Two weeks later labs failed to detect estradiol (<2.5 pg/ml). In other words, crashed. Empirical symptoms consistent with low estrogen. This is not the first time I’ve crashed my estrogen to...
  11. B

    Issues with Elevated Estradiol Levels

    I have been on TRT for about 9 months now and have had very marginal results to date. The protocol (.32ml T-Cyp, .50ml HCG & .25mg Anastrozole - twice per week) has elevated my T levels but my Estradiol levels have tracked proportionally upward. To date I have had very minimal increases in...
  12. J

    Higher Estradiol, Longer Telomeres in Men

    A press release from the university that conducted the study was reported by Medical Xpress. Here's a short extract from the article: "A new study of older men carried out by The University of Western Australia has found there is a link between men who have higher levels of the sex hormone...
  13. G

    TOT roundtable contradicting themselves once again

    So not trying to start anymore drama with the round table or anything, but I just can’t stand to see these guys contradict themselves like this. They all say that water retention is not a side effect of high E2, and that it’s either in our heads, has more to do with our diet, or it’s from the...
  14. A

    Peak and Trough E2 Variations

    I have been researching a lot of threads, not only on excelmale but many other boards as well. I noticed something interesting from the guys who pulled labs from both their peak and troughs. Men who were reading out between 20-30 on the sensitive E2 test were coming up as high as 60+ on their...
  15. Z

    Estrogen and sensitivity

    So after a long month of struggling with my erectile dysfunction I was able to be intimate with my wife for a whole session tonight )not saying that to boast there is a reason for me stating this) over the past month I have done tons of labs and research on here as well. People have been helpful...
  16. A

    Strategy to get E2 down just a little bit more

    50mg every 3.5 days of Test E 500iu every 3.5 days of HCG That protocol had my E2 @ 60pg/ml. and Test at 860 ng after 2 months it also put my Prolactin well over range. SHBG has been rock steady @ 35 nmol Changed to 100iu of HCG and in 6 weeks this brought my E2 down to 36 pg/ml. which I...
  17. Z

    New protocol

    So after going over labs today with my doctor. (Not going to post them, just because essentially from all the research I have done on this forum and others things seemed pretty normal.) I will just post the basics real quick tbiugh TT-917 E2 (ultra sensitive)-17 SHGB- 26 Prolactin- I can’t...
  18. Z

    New TRT doctor questions

    So I am following up with my new doctor that I saw on Wednesday. It was 45 minute consult just to explain what was going on. Why I am seeing him, why I went on TRT. Basically I explained to him I am tired that of the ups and downs that I have been experiencing on TRT. These ups can be for a week...
  19. Z

    Question on labs

    So I got my lab results today Free T-17.7 TT-797 E2-35 (roche test) SHGB 36.1 PSA-.9 I have been having some libido issues along with a little bit of mood issues. 3 weeks ago I was great. Now, kind of in the middle. Having difficulty getting erections and maintaining. Sex drive is pretty low...
  20. madman

    History of estrogen: its purification, structure, synthesis, biologic actions and clinical implications.

    . History of estrogen: its purification, structure, synthesis, biologic actions and clinical implications. - PubMed - NCBI Clark Sawin Memorial lecture on History of Estrogen delivered at Endo 2018: Player: Clark T Sawin Memorial History of Endocrinology Lecture: Estrogens Over 90 Years...
  21. lemonflavor

    High E2 On 70mg? Am I a Freak?

    54 year old male. I'm going to contact Defy, but I'm a little freaked out and wonder if anyone else has been here. I'll try to make it short: I'm on TRT for the second time around. I deal with chronic mental health issues and chronic pain which came about well before low T. First time around I...
  22. J

    Dr. Eugene Shippen on estradiol, aromatization...

    You can cut to the ~7minute mark.
  23. G

    Guys not tolerating HCG due to E2?

    Seems like a lot of guys here don’t feel good when HCG is part of their protocol. Then you have people that feel great on it. Do you guys think this is due to E2, or some other factor(s)? Just looking to see what you guys think about it. Thanks.
  24. rafapark

    The more I learn the more confused I am - DHEA and Estradiol

    These are my blood markers - all Labcorp Total Testosterone: 1080 ng/dl Free Testosterone: 19.2 pg/ml Estradiol sensitive: 34.2 pg/ml DHEA : 103 ug/dl IGF-1 : 206 ng/ml I started TRT in April of this year This is what I take Cypionate: 74 mg twice a week (0.37 ml twice a week) . (started with...
  25. M

    TRT for obese guy

    I weigh 250lbs @ 5'6, down from 300lbs. At my highest weight had a TT between 250ng/dl and 320ng/dl. I'm now up to 380ng/dl. My SHBG increased as well from 22 to 29. However, I've been noticing my symptoms getting worse as I've lost weight. For one, I'm a more depressed, apathetic and fatigued...
  26. T

    the E2 roller coaster is driving me nuts.

    I started TRT using lipo compounded cream in May of this year. at that point my E2 was a little high 32 (> 29) using QuestDiagnostics scale. My endo gave me 1mg anastrozole to take 3 times during the 1st week, and then 1mg once a week. In total, I believe it was 14mg over the course of 4-6...
  27. G

    Thoughts on my latest bloods?

    I've been on trt since early August. Still trying to dial in my protocol. I've just received my latest blood test results and interested to hear thoughts from those on this board. My protocol: 50mg testosterone enanthate every 2 days IM 250iu HCG every other 2 days SQ (so alternate between T...
  28. J

    Arimidex dosage timing schedule²

    Hello everybody, I am from France but i will try to do my best so you can understand me. My protocol is : Daily test 16mg HCG 500ui 2times a week And i need an AI but i wonder what is the best option of timing I am lean, i eat clean, and i do cardio and some weight lifting 2 to 3 times a week...
  29. Z

    Fatigue

    So 2 weeks my e2 bottomed out. Was exhausted as hell no libido the usual. Quit my AI. Move forward two weeks later, I have had sex a couple times with my wife. Libido has been up and down. Like today my exhaustion is high and no libido. Would it be my e2 is now super high? Or am I still...
  30. L

    Is Anastrazole truly necessary?

    Hi All, I was on a really bad TRT regimen for many many years (inject 300mg once every 3 weeks). I did not take HCG with my dose either. I was never monitored nor had blood panels. I was taking this dose from 2010 until 2018. I never bothered to get blood panels or check my hematocrit or E2 or...
  31. Gianluca

    is Soy really bad for us?

    I keep bumping into data of how Soy Phytoestrogens are good for us, men and women, but the best HRT doc's out there (TOTRoundtable) say the opposite, even the king of HRT Dr John Crisler is against them, so if he is against it there must be something true for sure. To my understanding one of...
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