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  1. BigTex

    Growth hormone replacement therapy reduces risk of cancer in adult with growth hormone deficiency: A meta-analysis

    Abstract The risk of growth hormone on cancer in adult with growth hormone deficiency remains unclear. We carried out a meta-analysis to evaluate the risk of cancer in adult with and without growth hormone replacement therapy. We searched PubMed, Web of Science, China National Knowledge...
  2. BigTex

    (CBD) Products for Pain: Ineffective, Expensive, and With Potential Harms

    Well folks, This pretty well sums up what I believe after using quite a few different product to relieve pain. Highlights • Cannabidiol (CBD) products have varying amounts of CBD, from none to much more than advertised. • CBD products may contain other chemicals than CBD, some of which may...
  3. BigTex

    EFFECT OF HIGH-INTENSITY INTERVAL TRAINING PROTOCOL ON ABS

    Haifeng Zhang, Tom K. Tong, Weifeng Qiu, Jingjing Wang, Jinlei Nie, Yuxiu He. EFFECT OF HIGH-INTENSITY INTERVAL TRAINING PROTOCOL ON ABDOMINAL FAT REDUCTION IN OVERWEIGHT CHINESE WOMEN: A RANDOMIZED CONTROLLED TRIAL. Kinesiology : international journal of fundamental and applied...
  4. BigTex

    Whole Eggs or Egg Whites?

    Stephan van Vliet, Evan L Shy, Sidney Abou Sawan, Joseph W Beals, Daniel WD West, Sarah K Skinner, Alexander V Ulanov, Zhong Li, Scott A Paluska, Carl M Parsons, Daniel R Moore, and Nicholas A Burd. Consumption of whole eggs promotes greater stimulation of postexercise muscle protein synthesis...
  5. BigTex

    Whole Milk vs Skimmed Milk: Effect on Cholesterol and Blood Sugar Level

    Abstract BACKGROUND/OBJECTIVES: Dietary guidelines have for decades recommended choosing low-fat dairy products due to the high content of saturated fat in dairy known to increase blood concentration of LDL cholesterol. However, meta-analyses including observational studies show no association...
  6. BigTex

    Rethinking Cholesterol and Saturated Fats in the Diet

    One of the top researchers in the world today is a guy who I have known since 1995, Jeff Volek, Ph.D., R.D. He is one of the leading experts in lipoprotein metabolism and ketogenic diets. Dr. Jeff Volek is a Professor in the Department of Human Sciences at The Ohio State University. A...
  7. BigTex

    Intensity of exercise and longevity

    https://www.mdpi.com/2076-3921/10/7/1035 Sellami M, Al-muraikhy S, Al-Jaber H, Al-Amri H, Al-Mansoori L, Mazloum NA, Donati F, Botre F, Elrayess MA. Age and Sport Intensity-Dependent Changes in Cytokines and Telomere Length in Elite Athletes. Antioxidants. 2021; 10(7):1035. Age and Sport...
  8. BigTex

    Enhanced Olympic Games?

    Olympics Without the Drug Tests: Enhanced Games Founder Lauds Steroid-Approved Event as ‘the Future of Sports’ https://enhanced.org/
  9. BigTex

    Effectiveness of a low dose testosterone undecanoate to improve sexual function in postmenopausal women

    Abstract Background Adding testosterone to hormonal therapy could improve sexual function and general well-being among women during climacteric. We evaluated the effectiveness of testosterone undecanoate on sexual function in postmenopausal women utilizing the standardized questionnaire FSFI...
  10. BigTex

    Protein: Is there a limit to how much we can use?

    I guess bodybuilders who eat huge amounts of protein have been right all along. So much for the 20g of protein bro science. Jorn Trommelen, Glenn A.A. van Lieshout, Jean Nyakayiru, Andrew M. Holwerda, Joey S.J. Smeets, Floris K. Hendriks, Janneau M.X. van Kranenburg, Antoine H. Zorenc, Joan...
  11. BigTex

    Is there hope for degenerative disk disease?

    SB-01 is a synthetic 7-amino acid peptide that binds to and induces down regulation of Transforming Growth Factor Beta 1 (TGFβ1), which is often highly expressed in the degenerated discs of patients with lower back pain. Abnormal TGFβ1 signaling is associated with the degradation of...
  12. BigTex

    Latest CBC Results

    I went in to Quest yesterday and did a CBC and IGF-1/GH test. I paid cash because insurance will not pay for IGF-1/GH. I had switched 20 days ago to cypionate (from TU) but instead of doing 40mg every 5 days I went 8mg every day. That dose before (40mg/5days) had a bad effect on my HCT. So...
  13. BigTex

    Is it impossible to get 10ml vials anymore?

    I went through the whole approval process with insurance (again) to get a 10ml vial of test cyp and opened up the box, it was a 1ml vial. That is good for 20 days (8mg/day) So before running out completely I went to the doctor to get a new script and complained. My doctor said he made it...
  14. BigTex

    Is GH for adult growth hormone deficiency now legal?

    I am hearing that in 2020, the FDA, at the request of Novo Nordisk (pharma), approved a product called Sogroya (somapacitan) for adults with growth hormone deficiency. Sogroya is the first human growth hormone (hGH) therapy that adult patients only take once a week by sub-q injection; other...
  15. BigTex

    Editing

    I was granted the ability to edit my posting anytime, mostly because I spell like crap. But today Somehow I made a double posting and wanted to delete the unfinished version and was not able to edit. In fact, I am unable to edit anything. What happened? NEVER mind......silly me. It was a PM...
  16. BigTex

    My Dilemma

    My doctor has put in an order for a blood dump, should I go or lower the dose slightly. September blood tests RED BLOOD CELL COUNT 5.66 Reference Range: 4.20-5.80 Million/uL HEMOGLOBIN 16.8 Reference Range: 13.2-17.1 g/dL HEMATOCRIT 50.4 H Reference Range: 38.5-50.0 PLATELET COUNT 281 Reference...
  17. BigTex

    The effect of vitamin D supplementation on depressive symptoms in adults

    Abstract Neurosteroid and immunological actions of vitamin D may regulate depression-linked physiology. Meta‐analyses investigating the effect of vitamin D on depression have been inconsistent. This meta-analysis investigated the efficacy of vitamin D in reducing depressive symptoms among adults...
  18. BigTex

    Reduced tissue creatine levels in patients with long COVID-19: does supplementation help?

    Total creatine concentration in the skeletal muscle and brain of long COVID patients were significantly lower when compared to the reference value. Will supplementing with creatine help restore these levels, thus reducing long Covid 19? We found that long COVID population is characterized by...
  19. BigTex

    Insulin-like growth factor-1 in articular cartilage repair for osteoarthritis treatment

    Osteoarthritis is a multi-factorial condition for which aging is the major risk factor. However, there are important differences between an aged joint and one with OA. The aging changes observed in the cells and extracellular matrix of joint tissues likely increase the susceptibility of older...
  20. BigTex

    Metformin, testosterone therapies lower risk for certain hormone-related cancers in men

    In a large cohort of men, pre‐diagnostic use of metformin and testosterone replacement therapy was associated with lower incidence of prostate and colorectal cancers, but not male breast cancer, according to research. “The greatest reduced risks of prostate and colorectal cancers were observed...
  21. BigTex

    The Timing of Protein

    This is a very good video by Lee Hayward on the timing of protein in your diet. This is not only used by bodybuilders but can be used by anyone to put together a good diet. This is all based on the digestion rates of different proteins depending on their fat content.
  22. BigTex

    Is training fasted optimal for hypertrophy and strength.

    Intermittent fasting is a huge trend now, how ever how effective is this diet when it comes to gaining muscle and strength. This study used an 16/8 type of intermittent fast most common on Muslim religions...
  23. BigTex

    Total Meat Intake is Associated with Life Expectancy

    You W, Henneberg R, Saniotis A, Ge Y, Henneberg M. Total Meat Intake is Associated with Life Expectancy: A Cross-Sectional Data Analysis of 175 Contemporary Populations. Int J Gen Med. 2022;15:1833-1851. Background: The association between a plant-based diet (vegetarianism) and extended life...
  24. BigTex

    Planks vs Isotonic Contractions: Does the strength transfer?

    Planks (isometric) vs Isotonic Contractions: Does the strength transfer? A plank exercise primarily involves an isometric muscular contraction. During a plank, you maintain a static position with your body in a straight line, and the muscles in your core, including the rectus abdominis...
  25. BigTex

    HOW TO TRAIN THE MUSCLES OF THE CORE

    Wrote the article today for work. It is based on a huge review of the current literature using EMGs. How to train the muscles of the core Core muscles generally refer to the group of six muscles located in the central part of your body. These muscles are essential for providing stability...
  26. BigTex

    Antiviral and immunomodulatory activity of curcumin

    Thimmulappa RK, Mudnakudu-Nagaraju KK, Shivamallu C, Subramaniam KJT, Radhakrishnan A, Bhojraj S, Kuppusamy G. Antiviral and immunomodulatory activity of curcumin: A case for prophylactic therapy for COVID-19. Heliyon. 2021 Feb;7(2):e06350. doi: 10.1016/j.heliyon.2021.e06350. Epub 2021 Feb 22...
  27. BigTex

    The Effects of Creatine Supplementation

    This is a meta-analysis so quite a few studies were combines. The authors found that creatine supplementation showed a beneficial effect for hypertrophy when compared to placebo. However, the size of the benefit was relatively small (0.11). The data showed similar improvements for both the...
  28. BigTex

    Men’s Sexual Health - Dr. Mohit Khera

    Men’s Sexual Health: why it matters, what can go wrong, and how to fix it Mohit Khera interviewed by Peter Attia MD Mohit Khera, M.D., M.B.A., M.P.H., Professor, is the Director of the Laboratory for Andrology Research at McNair Medical Institute, Baylor College of Medicine. He is also the...
  29. BigTex

    Had Covid 19 and lost your sense of smell?

    I had the mild version of Covid 19 over a year ago. Wasn't that bad but I feel like some of long covid symptoms may still be around. Having to do some intensive therapies to get rid of a lingering cough. I have also not been able to smell ANYTHING for over a year. This is called Anosmia...
  30. BigTex

    Diets and the use of Metformin

    My wife has been on a keto diet most of her life but she has always had some cravings for cabs and her appetite is very high. She is now trying a low carb diet with metformin and kind of likes being able to eat a few carbs. The strange thing is, carbohydrates always made her more hungry, with...
  31. BigTex

    Sleep Apnea Home Test

    I did a clinical sleep apnea test in 2007 and paid well over $5000 to get clinical testing done. Back then my insurance covered everything. If you don't have insurance it could be a problem and this sleep apnea problem needs to be controlled. I just saw this on CPAP.com. I have been using...
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