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I was using AI for some research, it made an interesting quick summary of Testosterone. I thought I would share. Pre-1935 – Theories of male virility Ancient and early medical theories linked testes with masculinity. Castration known to affect physical and behavioral traits. No chemical...

Lucky!

You are lucky. Are you injecting SubQ or IM? If subQ, what injection site(s) do you use?

I have not, thanks for bringing this up. Since injecting everyday, I generally get the blood draw about 2hrs post injection, but sometime I believe I went prior injection, and levels come back about the same. However, I have gone in the past in the late afternoon, and TT seems to come back...

it is still hard to believe to me my body is able to clear that fast testosterone even if I inject it daily, but I understand now that this can be the main reason why my levels are not above range with this dose. Unless at the cellular level things look different.

I just calculated again my FT with Tru calculator, and my FT is 18.64ng/dl, direct method is 19.4 pg/ml

throughout the years I used mostly the direct method. However, since the discussions in here, a couple years ago I started to use the Equilibrium ultrafiltration from LabCorp, and FT levels came back about the same as direct method. I also calculated FT with the Tru calculator, and FT matched...

Considering the daily natural production of a healthy young male, you would think that if someone inject 100mg tot weekly either using a daily or EOD protocol with an ester like Cypionate, we would see both TT and FT above range, theoretically. However, people like me: for example I inject...

it makes sense, especially with primary hypo. Perhaps then just like Thyroid and TSH, fully suppressing LH may mean we are taking in too much Test, or too much in one dose.

Doesn’t LH go to 0 regardless of the dose of testosterone used when using an ester like cypionate? I would guess then people daily microdosing with such a ester type don’t have their LH down to 0

@madman Do you believe then that when using TC/TE at once or twice per week injection schedule, is actually more advantageous/normal for the body, vs on a ED schedule when same ester is used since there is going to be a more pronounced peak and valley, even thought that is not lived daily?

I was doing some research with ai, according to anecdotes around the internet, subcutaneous injections seem to give more consistent results than nasal spray. I may try the injection.

How did it work for you? I'm currently looking at this or the Selank

also, when you running low on T3, the body will secrete more cortisol/adrenaline to compensate, that its self cause muscle loss

thanks for sharing!

At this point the blend Propionate/CYP or ENA to take daily, may be probably the best physiological option to get test into circulation considering metabolites conversion with some daily fluctuation in T, without letting testosterone dropping too low a couple of times in 24hr like the orals do...

@Vince Are you still injecting everyday IM?

as far as pharmacokinetics, if I remember correctly, scrotal cream applied once per day only is the closet to mimic endogenous T production. Too bad the DHT issue classify it far away from physiologic to me.

For sure

it doesn't raise serum levels, but it works. Less anxiety/stress and my skin looks better

I have been thinking about giving this a try, but I was looking at the inactive ingredients in both, and they sound pretty nasty.

This is what has been in my mind for the past few months. I think the issue with the scrotal cream is the unphysiologic conversion of T into DHT, I’m not sure what the general thought is now about the DHT. I would think an oral like Jatenzo would be the most physiological way to get Test into...

I remember commenting on this particular study here in the forum, this to be a concern for Progesterone not converting as much into allopregnenolone. Also, this study shows where the max physiological level of T are at about.

I think the Jatenzo/Kyzatrek overall are the closet to physiological we have, where do you get yours and how much monthly do you pay? I have been thinking to try it for a while now

I have some Preg capsule at home from Empower, BUD was 05-2023. I'm wondering if potency is still ok or it has been lost substantially, what do you guys think? toss it?

What Preg product are you using right now?

an update on my Hikma Test E trial vs Test CYP from empower. Levels are about the same, a bit less on the Hikma, Testosterone speaking I feel the same, I believe my head feels a bit more clear/natural on the Hikma. I think it is a good idea trying not to inject benzyl benzoate, some negative...

Not much of my intellect, really. You are bringing up good points. Though, oral steroids like DHEA and Pregnenolone, when going through the first pass metabolism get converted into different metabolites, I wouldn’t be surprised if scrotal application of the same steroids would produce a...

I should have mentioned to read the first post on the thread if interested, Hopefully that won’t be too gibberish for your level of intellect.

I'm not sure this has ever discussed here, but I found some very interesting data posted and commented by Georgi Dinkov AKA Haidut on the RayPeat forum, how applying Pregnenolone and DHEA (in DSMO) on the scrotum, can raise serum androgens like T DHT and Androsterone, this because directly...

I believe if someone is not using huge amount of test for prolonged time, I think probably there is not much to be concerned about the 5-ar. Lower levels of Progesteonre/Pregnenolone can be an issue for some