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Using tren or any other AAS (but T) alongside with psychiatric medications seems like a terrible idea. On the other hand there might be benefits: Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes - Excel Male Health Forum It might stop worsening of...

Proviron, Masteron, Oxandrolone is not (significantly) converted by 3α-HSD. Tren is converted by 3α-HSD into the more potent Tren-3α-ol. 3α-HSD: 3α-Hydroxysteroid Dehydrogenase If SSRIs on TRT are still needed and one doesn't notice any of the supposed mental benefits of TRT, I would suggest...

https://pmc.ncbi.nlm.nih.gov/articles/PMC23979/ "The enzymatic efficiency of the conversion of DHT to androstanediol increased 163-fold when the enzyme was incubated with fluoxetine and 63-fold with paroxetine but did not change substantially with imipramine. " Couldn't find follow-up...

Haven't heard of such side effects. If there is an underlying anxiety issue then I think it's possible that it could be triggered because dhea can have a stimulatory effect. I would take it in the morning.

Only knew Selank and Demax. Background information about AngII from deepseek: High-Level Summary Angiotensin IV (Ang IV) is a small peptide fragment (6 amino acids) derived from the larger Angiotensin II. For decades, it was considered an inactive metabolite. However, research has shown that...

Now I understand what you meant by SC is not working for you.

What's the difference in serum levels? Could you adapt the subq dose to match the IM levels? You could apply the cream to your shoulders. Another option is oral TU.

For me nandrolone was terrible even at a low dose. Currently the full name of tren is replaced by * indicating that it has no place in trt/hrt. Maybe it was never considered at very low dosages to supplement trt. Since on TRT, my impression is that I have more visceral fat relative to...

You are right. I think the Ctrl group should represent the healthy population. The high fat high sugar diet group represents the metabolic syndrome. .... With MetS and TD, tren showed benefits over test.

Vigorous Steve did research on this. For his body weight/composition about 25mg per week. I was looking into tren hex (Parabolan) bc of its long halflife. At low dose tren could work as sarm without spill over, i.e. sarm with anabolic and androgenic activity at muscle, fat, brain tissue. Maybe...

https://academic.oup.com/endo/article/157/1/368/2251856 "We propose that TEST replacement therapy may have contraindications for males with TD and obesity-related MetS. TREN treatment may be more effective in restoring androgen status and reducing cardiovascular risk in males with TD and MetS."...

The nebido protocol. For oral TU the data is then probably based on once daily protocol, resulting in less accumulated fT over the day and enough time to clear E2.

Why the difference between TU and TE/TC? What dose and injection intervall? When topical is mentioned it probably means Androgel. Not the same as twice daily high percentage Testo cream. Etcetera You provided a much clearer correlation, i.e. accumulated free T. Oral TU is outstanding. Why...

It's about Erythrocytosis. Maybe treat based on symptoms vs treat based on numbers. I recall an earlier study which linked E2 to Erythrocytosis, and it employed AI to manage it when E2 was high on modest TT levels.

The following article was cited: https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c02039 Finasteride, a 5-alpha reductase (5α-R) inhibitor, is a widely used drug for treating androgen-dependent conditions. However, its use is associated with sexual, psychological, and physical complaints...

What about dessert?

They should not misinform and mislead people.

Can you take about 4 weeks vacation or long-term cut your work hours in half? Can you take 2 months pause of fin? I guess your idea is that TRT gives that boost that would balance out your work stress. Maybe it would help (short term). Only opinions here, nobody can know for sure what's the...

Did you try magnesium supplements?

Yes. Your body will adjust. Maybe later you can tolerate more T and maybe it would give more benefits then.

Have recently added Q10 (mitochondria energy) and Rhodiola Rosea (dopamine).

Did anybody try dopamine nootropics? They usually have a short halftime, thus supposedly no interference with sleep. Rhodiola rosea, modafinil?

HGH makes me tired. Some use it before bedtime for better sleep.

Funny And probably no placebo effect with horses I took it 3 times per day. I think it reduced inflammation.

It helped me with knee pain.

What supplements have helped you?

https://www.cambridge.org/core/journals/psychological-medicine/article/comparative-efficacy-and-tolerability-of-nutraceuticals-for-depressive-disorder-a-systematic-review-and-network-metaanalysis/5799A126D0B5677764562824C452D545 Abstract Background Nutraceuticals have been taken as an...

Imo your hct was still good. I do not recommend you do blood donation to reduce your hct. Did you have any symptoms possibly related to hct?

IMO you have a very good absorption with SC injections. Imo your shbg looked better with 80mg. Could do 3x/w SC to achieve a higher trough level. That would get you closer to your magic number... You should include hct in your labs!

https://pmc.ncbi.nlm.nih.gov/articles/PMC6676071/ Figure 1

So true. Had here discussions about androgel T level dropping to the end of the day. One member here kept on posting studies that show that levels are stable. Finally evidence accumulated and serum tests showed differently. It wasn't only me... That 10-20% 'outliers' often get 'averaged out' in...