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Defy Medical TRT clinic doctor
  1. Seagal

    Please tell me how vitamin D supplementation has caused calcium deficiency, let's discuss.

    What my AI thinks The core of your problem almost certainly lies in the interplay between Vitamin D, Magnesium, and Parathyroid Hormone. · Most Likely Scenario (90% Confidence): You have an underlying magnesium deficiency. Supplementing Vitamin D exacerbates this deficiency, leading to impaired...
  2. Seagal

    Need honest advice: Do I really need TRT? Low-normal T, low libido for years, anxiety/OCD background, little muscle growth

    Regarding your concerns about fertility, you could search the forum for oral testosterone. I have no experience with it but that's what I would use (if I had access to it) to start or try TRT.
  3. Seagal

    Need honest advice: Do I really need TRT? Low-normal T, low libido for years, anxiety/OCD background, little muscle growth

    I asked my AI, it suggested you try TRT. Imo, it sounds multifactorial. It's difficult to give any advice. Do you have a problematic porn consumption?
  4. Seagal

    Lowering trt dose/ increasing frequency of injections question

    To me it makes no sense. Maybe some looking only at the trough level and chase a magic number.
  5. Seagal

    Lowering trt dose/ increasing frequency of injections question

    If you keep the weekly T dose constant and increase the injection frequency, it will flatten the curve, i.e. it will reduce the peak and increase the trough T levels.
  6. Seagal

    Tren Improves Cardiometabolic Risk Factors and Myocardial Tolerance to Ischemia-Reperfusion in Male Rats With Testosterone-Deficient Metabolic S

    This was your usual trt dose plus 5mg tren daily?
  7. Seagal

    Reaching orgasm

    Your T dose is probably too high. Is it 250mg/mL?
  8. Seagal

    Dihexa for Cognitive Enhancement

    Me neither. SLU-PP-332 did work for me but it is too expensive (EU).
  9. Seagal

    Tren Improves Cardiometabolic Risk Factors and Myocardial Tolerance to Ischemia-Reperfusion in Male Rats With Testosterone-Deficient Metabolic S

    That's my experience (Proviron, Anavar) but I felt like I had to state that. Nandrolone was terrible for me, however, most guys encounter only benefits.
  10. Seagal

    Tren Improves Cardiometabolic Risk Factors and Myocardial Tolerance to Ischemia-Reperfusion in Male Rats With Testosterone-Deficient Metabolic S

    Using tren or any other AAS (but T) alongside with psychiatric medications seems like a terrible idea. On the other hand there might be benefits: Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes - Excel Male Health Forum It might stop worsening of...
  11. Seagal

    Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes

    Proviron, Masteron, Oxandrolone is not (significantly) converted by 3α-HSD. Tren is converted by 3α-HSD into the more potent Tren-3α-ol. 3α-HSD: 3α-Hydroxysteroid Dehydrogenase If SSRIs on TRT are still needed and one doesn't notice any of the supposed mental benefits of TRT, I would suggest...
  12. Seagal

    Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes

    https://pmc.ncbi.nlm.nih.gov/articles/PMC23979/ "The enzymatic efficiency of the conversion of DHT to androstanediol increased 163-fold when the enzyme was incubated with fluoxetine and 63-fold with paroxetine but did not change substantially with imipramine. " Couldn't find follow-up...
  13. Seagal

    DHEA and Pregnenolone best times to take

    Haven't heard of such side effects. If there is an underlying anxiety issue then I think it's possible that it could be triggered because dhea can have a stimulatory effect. I would take it in the morning.
  14. Seagal

    Dihexa for Cognitive Enhancement

    Only knew Selank and Demax. Background information about AngII from deepseek: High-Level Summary Angiotensin IV (Ang IV) is a small peptide fragment (6 amino acids) derived from the larger Angiotensin II. For decades, it was considered an inactive metabolite. However, research has shown that...
  15. Seagal

    Help me make up my mind about a change in protocol

    Now I understand what you meant by SC is not working for you.
  16. Seagal

    Help me make up my mind about a change in protocol

    What's the difference in serum levels? Could you adapt the subq dose to match the IM levels? You could apply the cream to your shoulders. Another option is oral TU.
  17. Seagal

    Tren Improves Cardiometabolic Risk Factors and Myocardial Tolerance to Ischemia-Reperfusion in Male Rats With Testosterone-Deficient Metabolic S

    For me nandrolone was terrible even at a low dose. Currently the full name of tren is replaced by * indicating that it has no place in trt/hrt. Maybe it was never considered at very low dosages to supplement trt. Since on TRT, my impression is that I have more visceral fat relative to...
  18. Seagal

    Tren Improves Cardiometabolic Risk Factors and Myocardial Tolerance to Ischemia-Reperfusion in Male Rats With Testosterone-Deficient Metabolic S

    You are right. I think the Ctrl group should represent the healthy population. The high fat high sugar diet group represents the metabolic syndrome. .... With MetS and TD, tren showed benefits over test.
  19. Seagal

    Tren Improves Cardiometabolic Risk Factors and Myocardial Tolerance to Ischemia-Reperfusion in Male Rats With Testosterone-Deficient Metabolic S

    Vigorous Steve did research on this. For his body weight/composition about 25mg per week. I was looking into tren hex (Parabolan) bc of its long halflife. At low dose tren could work as sarm without spill over, i.e. sarm with anabolic and androgenic activity at muscle, fat, brain tissue. Maybe...
  20. Seagal

    Tren Improves Cardiometabolic Risk Factors and Myocardial Tolerance to Ischemia-Reperfusion in Male Rats With Testosterone-Deficient Metabolic S

    https://academic.oup.com/endo/article/157/1/368/2251856 "We propose that TEST replacement therapy may have contraindications for males with TD and obesity-related MetS. TREN treatment may be more effective in restoring androgen status and reducing cardiovascular risk in males with TD and MetS."...
  21. Seagal

    Controversies with Testosterone Therapy - Management of Erythrocytosis and Elevated Estradiol

    The nebido protocol. For oral TU the data is then probably based on once daily protocol, resulting in less accumulated fT over the day and enough time to clear E2.
  22. Seagal

    Controversies with Testosterone Therapy - Management of Erythrocytosis and Elevated Estradiol

    Why the difference between TU and TE/TC? What dose and injection intervall? When topical is mentioned it probably means Androgel. Not the same as twice daily high percentage Testo cream. Etcetera You provided a much clearer correlation, i.e. accumulated free T. Oral TU is outstanding. Why...
  23. Seagal

    Controversies with Testosterone Therapy - Management of Erythrocytosis and Elevated Estradiol

    It's about Erythrocytosis. Maybe treat based on symptoms vs treat based on numbers. I recall an earlier study which linked E2 to Erythrocytosis, and it employed AI to manage it when E2 was high on modest TT levels.
  24. Seagal

    Thinking about TRT and could use some guidance

    The following article was cited: https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c02039 Finasteride, a 5-alpha reductase (5α-R) inhibitor, is a widely used drug for treating androgen-dependent conditions. However, its use is associated with sexual, psychological, and physical complaints...
  25. Seagal

    The holy Grail of nutritional research regarding red meat consumption and lack of evidence of harm.

    What about dessert?
  26. Seagal

    Wild ride! Went from 120mg > 100mg > 80mg > 90mg. T is higher at 90mg 3x a week than 100mg 2x a week

    They should not misinform and mislead people.
  27. Seagal

    Thinking about TRT and could use some guidance

    Can you take about 4 weeks vacation or long-term cut your work hours in half? Can you take 2 months pause of fin? I guess your idea is that TRT gives that boost that would balance out your work stress. Maybe it would help (short term). Only opinions here, nobody can know for sure what's the...
  28. Seagal

    Tight or knotted muscles from TRT?

    Did you try magnesium supplements?
  29. Seagal

    Wild ride! Went from 120mg > 100mg > 80mg > 90mg. T is higher at 90mg 3x a week than 100mg 2x a week

    Yes. Your body will adjust. Maybe later you can tolerate more T and maybe it would give more benefits then.
  30. Seagal

    Comparative efficacy and tolerability of nutraceuticals for depressive disorder: A systematic review and network meta-analysis

    Have recently added Q10 (mitochondria energy) and Rhodiola Rosea (dopamine).
  31. Seagal

    DHT Cream Plus Testosterone Propionate = Major Libido Boost

    Did anybody try dopamine nootropics? They usually have a short halftime, thus supposedly no interference with sleep. Rhodiola rosea, modafinil?
TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

Defy Medical TRT clinic doctor
Defy Medical TRT clinic

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