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Defy Medical TRT clinic doctor
  1. C

    Why do some men need supraphysiological doses of testosterone to achieve normal levels

    I didn't ask if you have ruled out fast absorption. To do this properly you need several samples of serum testosterone during the day to estimate area-under-the-curve. But it might suffice to see what your testosterone level is two to fours hours post-injection. If it is extremely high then you...
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    Why do some men need supraphysiological doses of testosterone to achieve normal levels

    It's an interesting hypothesis, but I'm not aware of any supporting data, and there is some pointing against it. For example, in one of the testosterone dose-response trials free testosterone remained proportional to dose even at very high doses of testosterone. Now I guess you could argue that...
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    Why do some men need supraphysiological doses of testosterone to achieve normal levels

    It only works that way if you're measuring total testosterone on an absolute basis, e.g. the total milligrams in plasma. But we're measuring the total concentration in blood, which is mostly bound to the effective reservoir of SHBG and albumin. This means the concentration of total testosterone...
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    Why do some men need supraphysiological doses of testosterone to achieve normal levels

    Weight is probably related only indirectly to the observations. Obesity would be strongly correlated with metabolic syndrome and low SHBG. The low SHBG is what drives down total testosterone, but not free testosterone. Therefore it's unlikely that heavier men on TRT actually need higher doses...
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    Why do some men need supraphysiological doses of testosterone to achieve normal levels

    In fact this is usually the case. 100 mg per week in divided doses puts my total testosterone over 1,200 ng/dL, and this is common. @Readalot shared data supporting this proposition. Your low SHBG suppresses total testosterone. Free testosterone is proportional to the dose rate. By what method...
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    Peptides for arthritis?

    The ibutamoren is taken at bedtime, hours after the last meal. I've been using a continuous glucose monitor and there's no evidence of negative effects in this regard. Which is to say that it didn't make things worse. But my Hba1c was already running high in the reference range in spite of good...
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    Peptides for arthritis?

    Fortunately this assessment appears to be overly pessimistic. Phase 3 of the Sprifermin trial is ongoing, and researchers envision public access to this treatment soon. [R] I can also report that I have overcome the hurdles and obtained FGF-18, basically using the techniques you mention above...
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    testosterone super high on 200mg

    Opinions vary, but mine is that "real" TRT excludes going much over 100 mg of testosterone cypionate per week. That's because this is beyond the physiological production range. Your 200 mg is double this, and at 20 mg of testosterone per day that's giving you about triple what a healthy young...
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    Enclomiphene on TRT for Fertility

    Assuming secondary hypogonadism, then with few exceptions enclomiphene will not restore or maintain fertility with any form of TRT that keeps serum testosterone at mid to high levels continuously. These forms of TRT include injections of testosterone esters, topical testosterone products and...
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    Weekly shot lab timing

    It is considered standard practice to measure testosterone at trough when on TRT. However, measuring at the midway point can give a better sense of your average level throughout the injection cycle. The danger here is that your doctor may see that it's pretty high and want to make some changes...
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    Regular testosterone test overestimates hypogonadism in men compared to the LC-MS/MS assay

    Even with secondary hypogonadism you could give small enough doses of testosterone cypionate such that LH would not go to zero. However, the contrast is that with secondary the brain is calling its low testosterone level "normal", so any exogenous testosterone immediately works to suppress the...
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    Shallow Testosterone IM versus SubQ Injections - Lab Results

    Any rigorous evidence for this? Until then I'll go by the studies measuring areas-under-the-curve, which do not find a difference between SC and IM. I don't discount that differing absorption rates can affect other parameters, but I remain skeptical of the disappearing-testosterone hypothesis.
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    Gel vs injection

    I would reject the claim that gels are more physiological than injections. In some cases the diurnal rhythm in serum testosterone is more natural looking. But I think this is outweighed by DHT levels that are often not physiological. Even when DHT is in range it may be relatively large compared...
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    Regular testosterone test overestimates hypogonadism in men compared to the LC-MS/MS assay

    In fact these more complicated techniques are better suited for treating secondary hypogonadism. With short-acting testosterone the troughs in serum testosterone are low enough and long enough that even the overly-sensitive HPTA experiences less suppression. Meanwhile, the peaks to mid- or...
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    Regular testosterone test overestimates hypogonadism in men compared to the LC-MS/MS assay

    No, it can be much simpler than that. I believe it's sufficient to provide a fixed background level of testosterone. Then the HPTA can handle the rest with its natural variations. As a simple example, suppose a guy would normally have morning testosterone of 600 ng/dL, but develops testicular...
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    Regular testosterone test overestimates hypogonadism in men compared to the LC-MS/MS assay

    There were a couple guys on the old PeakTestosterone forum successfully using this approach. With primary hypogonadism the HPTA feedback mechanisms are largely intact; the brain is calling for a healthy amount of testosterone, but the testicles cannot respond adequately. Therefore it is possible...
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    Concerned about hair loss: TRT + deca vs TRT alone vs deca alone

    A conservative approach that should promote your goals: use a short-acting form of testosterone; switch to topical finasteride and/or dutasteride; use ibutamoren if IGF-1 is below average. Short-acting forms of testosterone include nasal gels, buccal troches and micronized testosterone...
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    Regular testosterone test overestimates hypogonadism in men compared to the LC-MS/MS assay

    One good thing about primary hypogonadism is that testosterone (augmentation) therapy is relatively low risk if you adopt a low-and-slow approach and titrate to achieve normal LH and FSH. In this case you can achieve supplementation without replacement; your HPTA feedback loop keeps operating...
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    Is Fiber Really Essential?

    Grok to the rescue: Direct Answer Research suggests a high-fiber diet likely improves health, with strong evidence for benefits like better digestion, heart health, and blood sugar control. The evidence leans toward reduced risks of heart disease, type 2 diabetes, and certain cancers, though...
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    Where to buy peptides?

    Assuming you're in the United States: Many of these peptides are not FDA approved and cannot legally be sold for human use. With respect to the ones that are approved, they generally require a prescription and must be made at approved facilities. All of this regulation is bypassed when the...
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    High Testosterone, is this expected?

    This is not too unusual. There's at least one study finding absorption via scrotal skin to be over 50%. Consider that healthy young men typically produce 6-7 mg of testosterone daily. You're potentially getting into the realm of four times that with your two doses. It's different at other...
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    Starting TRT Soon

    Not above average, above range. This means more than two standard deviations above average. In general there are all kinds of negative associations when hormones are out of range, not least of which is reduced longevity. Although long-term research is lacking, specific to testosterone there are...
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    Starting TRT Soon

    It's the opposite. The majority should not be dosed excessively just because the more-is-better minority is louder and more demanding. No, it isn't. It makes no sense to start TRT at a dose that is effectively above the physiological production range. Even the recommended starting dose for...
  24. C

    enclomiphone lowered my testosterone

    Throwing out a couple possibilities: Your SHBG dropped between the measurements, such that an increase in free testosterone was concealed. Or you actually have primary hypogonadism, i.e. testicular insufficiency. Have you tested LH?
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    GHK-cu and DHT

    I agree that Peptide Sciences is considered the most trustworthy, though ironically I have had a couple of QC issues with them. I also use Nootropic Source because they have a good price on GHK-Cu in quantity. However, I have not done any independent testing to quantify things.
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    Starting TRT Soon

    It's likely much more testosterone than you could ever have produced naturally, heightening your risk of side effects. But I'm primarily emphasizing a low-and-slow approach. If you had started low and slowly titrated up to this while seeing improvements then I would not characterize it as an...
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    GHK-cu and DHT

    We're largely on our own with this. There's this frequent argument that we should take breaks, but it seems to be based more on speculation and caution than anything concrete. Assuming copper intake is reasonable, my hope is that as with testosterone, the short half-life and pulsatile delivery...
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    Starting TRT Soon

    The main argument is that you should establish a baseline at physiological levels, so that if you as an informed adult want to experiment with higher levels then at least you'll know if you're making things better or worse. All too often people feel bad starting with high levels and then assume...
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    Starting TRT Soon

    Don't ignore the key qualification in my posts: starting out Even so, I can point to Xyosted. Only three doses, 50, 75 and 100 mg TE per week, which are obviously covering the vast majority of men. For reader clarity: note the difference between pure testosterone and testosterone cypionate...
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    Starting TRT Soon

    Let's see the documentation. What is the incidence of this purported condition? One in tens of thousands? I'm betting it has essentially no bearing on the average guy starting TRT. So what. Are you aware that the normal production range is about 3-9 mg per day? Yet you're defending starting out...
  31. C

    Starting TRT Soon

    That's 12 mg a day of testosterone, more than almost every man makes naturally. Of course it's too much. I don't see how anybody can defend starting out with a dose this high or higher. This should only happen if you tell your doctor that anabolism is your number one priority and you knowingly...
TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

Defy Medical TRT clinic doctor
Defy Medical TRT clinic

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