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  1. C

    Is Fiber Really Essential?

    Grok to the rescue: Direct Answer Research suggests a high-fiber diet likely improves health, with strong evidence for benefits like better digestion, heart health, and blood sugar control. The evidence leans toward reduced risks of heart disease, type 2 diabetes, and certain cancers, though...
  2. C

    Where to buy peptides?

    Assuming you're in the United States: Many of these peptides are not FDA approved and cannot legally be sold for human use. With respect to the ones that are approved, they generally require a prescription and must be made at approved facilities. All of this regulation is bypassed when the...
  3. C

    High Testosterone, is this expected?

    This is not too unusual. There's at least one study finding absorption via scrotal skin to be over 50%. Consider that healthy young men typically produce 6-7 mg of testosterone daily. You're potentially getting into the realm of four times that with your two doses. It's different at other...
  4. C

    Starting TRT Soon

    Not above average, above range. This means more than two standard deviations above average. In general there are all kinds of negative associations when hormones are out of range, not least of which is reduced longevity. Although long-term research is lacking, specific to testosterone there are...
  5. C

    Starting TRT Soon

    It's the opposite. The majority should not be dosed excessively just because the more-is-better minority is louder and more demanding. No, it isn't. It makes no sense to start TRT at a dose that is effectively above the physiological production range. Even the recommended starting dose for...
  6. C

    enclomiphone lowered my testosterone

    Throwing out a couple possibilities: Your SHBG dropped between the measurements, such that an increase in free testosterone was concealed. Or you actually have primary hypogonadism, i.e. testicular insufficiency. Have you tested LH?
  7. C

    GHK-cu and DHT

    I agree that Peptide Sciences is considered the most trustworthy, though ironically I have had a couple of QC issues with them. I also use Nootropic Source because they have a good price on GHK-Cu in quantity. However, I have not done any independent testing to quantify things.
  8. C

    Starting TRT Soon

    It's likely much more testosterone than you could ever have produced naturally, heightening your risk of side effects. But I'm primarily emphasizing a low-and-slow approach. If you had started low and slowly titrated up to this while seeing improvements then I would not characterize it as an...
  9. C

    GHK-cu and DHT

    We're largely on our own with this. There's this frequent argument that we should take breaks, but it seems to be based more on speculation and caution than anything concrete. Assuming copper intake is reasonable, my hope is that as with testosterone, the short half-life and pulsatile delivery...
  10. C

    Starting TRT Soon

    The main argument is that you should establish a baseline at physiological levels, so that if you as an informed adult want to experiment with higher levels then at least you'll know if you're making things better or worse. All too often people feel bad starting with high levels and then assume...
  11. C

    Starting TRT Soon

    Don't ignore the key qualification in my posts: starting out Even so, I can point to Xyosted. Only three doses, 50, 75 and 100 mg TE per week, which are obviously covering the vast majority of men. For reader clarity: note the difference between pure testosterone and testosterone cypionate...
  12. C

    Starting TRT Soon

    Let's see the documentation. What is the incidence of this purported condition? One in tens of thousands? I'm betting it has essentially no bearing on the average guy starting TRT. So what. Are you aware that the normal production range is about 3-9 mg per day? Yet you're defending starting out...
  13. C

    Starting TRT Soon

    That's 12 mg a day of testosterone, more than almost every man makes naturally. Of course it's too much. I don't see how anybody can defend starting out with a dose this high or higher. This should only happen if you tell your doctor that anabolism is your number one priority and you knowingly...
  14. C

    Why do most say other hormones deplete while on TRT?

    While it's unequivocal that exogenous testosterone can affect a large number of other hormones/precursors by disrupting various feedback loops, the argument would be that it's statistical in nature, with substantial variation between individuals. It's more clear-cut with hormones such as LH and...
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    Syringe Holder/Loader

    Another simple option, a piece of stiff wire bent to hold the vial and hang it from something. A wood chip, syringe cap, etc. holds the plunger out:
  16. C

    What it the purpose of Sex Hormone Binding Globulin (SHBG) ?

    In fact I recall at least two or three examples posted over the years, though I'd be hard pressed to find them. I believe @Gman86 was one of them. The idea is that a guy on TRT maintains that dosing while adding some other androgenic steroid. The outcome is typically a double whammy for SHBG...
  17. C

    What it the purpose of Sex Hormone Binding Globulin (SHBG) ?

    Yes, and the AI misinterpreted them, as shown in detail above. That's not what's being said. In the specific case of free testosterone and SHBG the same rules do apply, because selecting the dose rate under TRT is analogous to the body's direct regulation of free testosterone by altering its...
  18. C

    What it the purpose of Sex Hormone Binding Globulin (SHBG) ?

    It also applies to TRT. Grok 3 again: Conclusion Given that testosterone metabolism follows first-order kinetics with respect to free testosterone, and at steady state the dose rate equals the elimination rate, the free testosterone level is indeed directly proportional to the dose rate. The...
  19. C

    What it the purpose of Sex Hormone Binding Globulin (SHBG) ?

    Battle of the AIs. This is Grok 3: I agree with your assessment that in normal physiology, it’s a misconception to think that the level of Sex Hormone-Binding Globulin (SHBG) directly affects the amount of free testosterone. Here’s why: Understanding SHBG and Testosterone SHBG is a protein...
  20. C

    Re use the individual Cypionate vials or throw away?

    If these are glass ampules that you break open then you need to transfer the contents to a normal stoppered vial to preserve sterility. I would also verify that a preservative is included in the formulation and ideally use a filter needle to remove possible glass fragments.
  21. C

    Re use the individual Cypionate vials or throw away?

    I and many of the guys here have been known to use such vials for many months. While there's no guarantee something bad won't happen, the odds of that are clearly small. From the standpoint of microbial contamination, you can be less concerned if you're injecting subcutaneously because a shallow...
  22. C

    Starting TRT Soon

    Allow me to offer an even more conservative perspective. That 100 mg per week of testosterone cypionate would already be giving you more testosterone than most men ever make naturally. The average testosterone production for healthy young men is equivalent to around 60-70 mg of testosterone...
  23. C

    Ran out of wife's testosterone-can she use mine?

    Short answer: It's fine. Long answer: Assuming you mean she takes 0.07 mL TC @ 50 mg/mL, this is 3.5 mg TC. So as you say, taking a quarter of the volume of your 200 mg/mL TC—0.0175 mL—does yield the same 3.5 mg dose of TC. I wouldn't hesitate to do it. Your only issue is the precision of the...
  24. C

    Dosage recommendations when switching esters.

    In my estimation, if you preserve daily peak testosterone then the transition should be relatively smooth. Using my own measurements I can give you a rough estimate of how much to lower the dose. Daily cypionate is assumed to give pretty flat serum testosterone. For me, at least, daily...
  25. C

    Compounding Pharmacies and Test Raws and Tariffs

    I wouldn't panic. Particularly for compounded testosterone, the price of the raw material has to be a fairly small fraction of the end product price. Only somewhat more so for UGL. For example, one AI puts the bulk price per kilogram of testosterone cypionate at $500-$2,000. Via Defy Medical...
  26. C

    current protocol for preserving testicular function with TRT

    HCG monotherapy is a reasonable choice given the concerns about fertility. Anecdotes tend to disfavor it with respect to subjective results. This may be due to the potential for excess aromatization. But some guys seem happy with it. Let me throw in Dr. Saya's fertility ranking to give you an...
  27. C

    current protocol for preserving testicular function with TRT

    Usually there's a minimum of 250 IU hCG twice a week up to a maximum of maybe 500 IU three times a week. Around 750-1,000 IU per week in divided doses is typical.
  28. C

    current protocol for preserving testicular function with TRT

    Various options for increasing testosterone while preserving testicular function: TreatmentProsCons Conventional TRT + hCGEffective, usually preserves fertility, higher testosterone levels if neededCost, sometimes extra injections, often excess aromatization, upstream HPTA suppression...
  29. C

    Does HCG Cause Alzheimer's Disease?

    Good discussion and references here: https://www.excelmale.com/threads/hcg-and-elevated-lh-in-alzheimer-patients.25431/
  30. C

    Hesitating on TRT, Does Anyone Have Regrets?

    Unfortunately PeakTestosterone.com is gone, so I am unable to point you to threads with guys using dose-tuning to manage primary hypogonadism. Keep in mind that what you've read about suppression when dosing to symptom resolution almost certainly pertains to secondary hypogonadism. Even this...
  31. C

    Hesitating on TRT, Does Anyone Have Regrets?

    Cypionate is preferred for its greater reliability and precision in dosing. You'll want to inject at least twice a week so that you'll have a stable background level. Then your natural regulation can do the rest. It's great that your endo wants to target normal LH and FSH. Many would just...
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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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