Testosterone anxiety?

stickersteve · Jun 17, 2025

I have been on transscrotal testosterone crème for about a month now. All of a sudden my anxiety is as bad as it has ever been. I am not blaming the testosterone, but is it a possibility? If so do all methods of testosterone cause possible anxiety?

Seagal · Jun 17, 2025

stickersteve said:
I have been on transscrotal testosterone crème for about a month now. All of a sudden my anxiety is as bad as it has ever been. I am not blaming the testosterone, but is it a possibility? If so do all methods of testosterone cause possible anxiety?

Yes. Yes. The stimulatory effect of T can cause anxiety in some men. Sometimes an imbalance of dht to e2 can cause anxiety. Most likely it's too much of either t, dht, or e2. Lowering the dose should ease/resolve the anxiety. You can increase the dose later, if needed. Your body/brain might need more time to adjust to the new (probably high) level of sex hormones.

stickersteve · Jun 17, 2025

Seagal said:
Yes. Yes. The stimulatory effect of T can cause anxiety in some men. Sometimes an imbalance of dht to e2 can cause anxiety. Most likely it's too much of either t, dht, or e2. Lowering the dose should ease/resolve the anxiety. You can increase the dose later, if needed. Your body/brain might need more time to adjust to the new (probably high) level of sex hormones.

ok, thank you. maybe i will go to one click rather than 2 or try another form of trt

Systemlord · Jun 17, 2025

stickersteve said:
I have been on transscrotal testosterone crème for about a month now. All of a sudden my anxiety is as bad as it has ever been. I am not blaming the testosterone, but is it a possibility? If so do all methods of testosterone cause possible anxiety?

I think you should get your testosterone levels checked.

WhiteMale · Jun 18, 2025

You can alternated scrotum with your wrist of deltoids, or halve your dose between application spots see if that eases some of the DHT/T/E levels you might be seeing.

Jerajera · Jun 18, 2025

Too much E2 for me leads to anxiety. Strong E2 peaks such as the ones from hCG actually give me panic attacks which I've never had my entire life before starting TRT.

For me at least, higher androgenic state (higher DHT:E2 ratio) is less anxiety, more confidence, etc...high estrognic state the opposite

john.davidson25 · Jun 29, 2025

Unfortunately if you have hypogonadism, anxiety will your friend for life. 90% of your treatment will revolve around controlling T dosaging so you avoid/address issues of anxiety, depression, fatigue, etc. I've been dealing with this for a very long time and I don't remember a time when I don't have anxiety.