New Defy Medical Patient - Please Critique Protocol

What's your SHBG? Any history of gyno? Was your E2 test a sensitive test? What's the range? There are many variables that play into this, so I'm just guessing here.


shbg 30 , range 16-55
Gyno - not really but one side has a little more fat than the other side, so maybe
E2 was sensitive, 30, range 8-35
 
You can get on the Defy website and fill out the contact us with any questions you have. I have always sent a email too [email protected] with ATTN Medical and the email will be sent to medical staff. You can also call them, either way they are extremely helpful and will address all concerns and questions you may have. I am like you, as soon as the call ends I suddenly have all sorts of things I didnt get clarification on during the call.

edit...wanted to add, your protocol is nearly identical to mine when I began TRT. I had thought the AI crashed my E2 at 4 weeks in, contacted defy, a T-Level and E2 blood test was ordered for me. Found out I was High E2. They upped my AI and ordered more labs, we got it down to 35 now, with my true follow up coming up in 2 weeks. I was not charged for the extra calls/emails and ordering of labs. Defy is there to truly help, not just make a fast buck on the Low T craze.
 
Thanks for all the input guys! My TRT was just delivered today so can't wait to go home and get started. I will be starting a log soon to show my journey to 8% BF hahaha
 
On the thyroid side ... Yeah, the results look pretty hypothyroid like. Probably 'Secondary' based on the low TSH in relation to FT4 and FT3. Your FT3 is at 29% of the reference range, which is where I would probably expect it to with taking only a 1/2 grain of NDT. Aiming towards the 50% to 80% area of reference range is usually ideal for most; 60%sh works good for me.

The one variable you need in the mix before trying to optimize is your Reverse T3. If RT3 is elevated, or it's ratio is out of line with FT3, that's usually a key marker that something else needs addressed, i.e., iron, ferritin, cortisol ... In that case, increasing FT3 is going to be somewhat problematic, more than likely leading to FT3 pooling. Without getting too deep into everything related with this, just run your RT3 and FT3 together, post it up, I'll give you my .02 as will others. Also, I see your TPO antibodies, but equally of importance is the TgAb assay, which covers autoimmune at the protein level of the thyroid.
 

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⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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